metallothioneins

metallothioneins

a group of CYSTEINE-rich PROTEINS that bind heavy metals, such as Zn ions, and have a role in HOMEOSTASIS and DETOXIFICATION.
References in periodicals archive ?
In kidneys, mainly [Hg.sup.2+] has affinity with metallothioneins (MTs), thus exposure to [Hg.sup.0] affects induction of synthesis of MTs in kidneys.
In animals and protists bioaccumulation of heavy metals is based on glutathione and metallothioneins (MTs) (Binz and Kagi, 1999).
Cephalopods present several metalloproteins, including metallothioneins (MTs), a group of proteins that have been extensively studied in different animal groups [28, 30, 43, 44, 45].
The rigorous [Zn2.sup.+] regulation is conducted by Zn transporters (ZnTs and ZIPs) and metallothioneins (MTs) [108, 109].
Metallothioneins (MTs) are a family of small cysteine-rich proteins, located in the membrane of the Golgi apparatus in the cells of virtually all living organisms.
High levels of Zn and Cu in the liver also are connected to natural protein binding such as Metallothioneins [18].
(17.) Noel-Lambot GC, Disteche A (1978) Distribution of Cd, Zn and Cu in liver and gills of the Eel, Anguilla anguilla with special reference to metallothioneins. Comp Biochem Physiol C Comp Pharmacol 61: 177-187.
The increased hepatic Zn concentration resulting from ZnPal supplementation observed in this study may be associated with its modulation on the mRNA abundances of metallothioneins and Zn transporters, the key mediators for Zn adsorption and transportation, as previously reported in broiler chickens [19] and laying hens [23] when supplemented with Zn bearing zeolite clinoptilolite.
This finding is in agreement with the results obtained in solitary ascidians, which saw an increase in the transcription of genes for GCLC, GCLM, GS, metallothioneins, phytochelatin synthase, and SODb in Ciona intestinalis after treatment with 10 [micro]mol [l.sub.-1] Cd[Cl.sub.2] (Franchi et al., 2011, 2012, 2014; Ferro et al., 2013).
With high levels of zinc, there is an increase in metallothioneins, proteins that bind zinc to prevent its absorption.
Aschner, "Astrocyte metallothioneins (MTs) and their neuroprotective role," Annals of the New York Academy of Sciences, vol.

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