metallothionein


Also found in: Acronyms, Encyclopedia, Wikipedia.

me·tal·lo·thi·o·nein

(me'tal-ō-thī'ō-nēn),
Any of a group of small proteins, rich in cysteinyl residues, that is synthesized in the liver and kidney in response to the presence of divalent ions (for example, zinc, mercury, cadmium, copper) and that binds these ions tightly; of importance in ion transport and detoxification; the apoprotein is thionein.

metallothionein

A family of low-molecular-weight, cysteine-rich proteins present in various tissues, which bind functional (e.g., copper, selenium, zinc) and toxic (e.g., arsenic, cadmium, mercury, silver) metal ions. Metallotheonein production is stimulated by heavy metals (e.g., cadmium and mercury) and is involved in transport, storage, and regulation of “natural” metal ions.

me·tal·lo·thi·o·nein

(mĕ-tal'ō-thī'ō-nē'in)
A small protein, rich in cysteinyl residues, which is synthesized in the liver and kidney in response to the presence of divalent ions (zinc, mercury, cadmium, copper) and that binds these ions tightly; of importance in ion transport and detoxification.
Mentioned in ?
References in periodicals archive ?
An investigation of modifying effects of metallothionein single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels.
Gumulec et al., "The role of metallothionein in oxidative stress," International Journal of Molecular Sciences, vol.
Howarth, "The role of zinc and metallothionein in the dextran sulfate sodium-induced colitis mouse model," Digestive Diseases and Sciences, vol.
Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues.
According to [66,67], cadmium causes reductions in both intestinal zinc absorption and hepatic zinc reserves in cattle, respectively, as a result of competition for the cation-binding sites of metallothionein (MT).
Liu, "Expression patterns of metallothionein, cytochrome P450 1A and vitellogenin genes in western mosquitofish (Gambusia affinis) in response to heavy metals," Ecotoxicology and Environmental Safety, vol.
Moreover, metallothionein, a potent antioxidant [58], was identified to be a downstream target of Nrf2 and predominantly mediated SFN's protective effects on diabetic nephropathy [18] and DCM [31].
It has been reported that astrocytes have a great influence in cerebral copper homeostasis and they can store big amounts of this metal due to specific characteristics as vast amounts of DMT1, ferritin, metallothionein, and antioxidants as glutathione (GSH) [13, 16, 17].
One mechanism through which Cd could promote PC increased synthesis of metallothionein since positive staining for metallothionein in pancreatic carcinomas was often associated with worse histological grade of carcinoma, liver metastases, and shorter survival as shown by Ohshio et al.
Cadmium accumulation, metallothionein and glutathionein levels and histopathological changes in the kidneys and liver of magpie (Pica pica) from a zinc smelter area.
Liver, being a regulatory organ, is a main site, where bioaccumulation of metals takes place because of its detoxifying nature through the production of metallothionein (Canli and Atli, 2003).

Full browser ?