An investigation of modifying effects of metallothionein
single-nucleotide polymorphisms on the association between mercury exposure and biomarker levels.
Gumulec et al., "The role of metallothionein
in oxidative stress," International Journal of Molecular Sciences, vol.
Howarth, "The role of zinc and metallothionein
in the dextran sulfate sodium-induced colitis mouse model," Digestive Diseases and Sciences, vol.
Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein
in biological tissues.
Evaluation of involvement of testicular metallothionein
gene expression in the protective effect of zinc against cadmium-induced testicular pathophysiology in rat.
According to [66,67], cadmium causes reductions in both intestinal zinc absorption and hepatic zinc reserves in cattle, respectively, as a result of competition for the cation-binding sites of metallothionein
Liu, "Expression patterns of metallothionein
, cytochrome P450 1A and vitellogenin genes in western mosquitofish (Gambusia affinis) in response to heavy metals," Ecotoxicology and Environmental Safety, vol.
, a potent antioxidant , was identified to be a downstream target of Nrf2 and predominantly mediated SFN's protective effects on diabetic nephropathy  and DCM .
It has been reported that astrocytes have a great influence in cerebral copper homeostasis and they can store big amounts of this metal due to specific characteristics as vast amounts of DMT1, ferritin, metallothionein
, and antioxidants as glutathione (GSH) [13, 16, 17].
One mechanism through which Cd could promote PC increased synthesis of metallothionein
since positive staining for metallothionein
in pancreatic carcinomas was often associated with worse histological grade of carcinoma, liver metastases, and shorter survival as shown by Ohshio et al.
Cadmium accumulation, metallothionein
and glutathionein levels and histopathological changes in the kidneys and liver of magpie (Pica pica) from a zinc smelter area.
Liver, being a regulatory organ, is a main site, where bioaccumulation of metals takes place because of its detoxifying nature through the production of metallothionein
(Canli and Atli, 2003).