metalloproteinase inhibitor


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Related to metalloproteinase inhibitor: metalloprotease inhibitor

metalloproteinase inhibitor

Any of numerous compounds that inhibit the activity of the metalloproteinase family of enzymes. These agents share the ability to suppress or eliminate the enzyme activity of the metalloproteinases. Agents identified in this group include the tetracycline antibiotics, numerous specially designed synthetic peptides and proteins, chemicals such as ethylenediaminetetra-acetic acid (EDTA), and a variety of agents used in cancer chemotherapy. Synonym: metalloprotease inhibitor
See also: inhibitor
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Matrisian, "Matrix metalloproteinase inhibitors and cancer: trials and tribulations," Science, vol.
Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha (v) beta (3) receptor blockade.
In addition, the general metalloproteinase inhibitor TAPI-1 or the more specific ADAM10 inhibitor GI254023 both reduced shedding in THP-1 cells.
In the present study, we have shown that SalA as a novel metalloproteinase inhibitor with relative specificity for MMP-9 is at least as effective as Dox, a full-spectrum MMP inhibitor, in preventing the growth of aortic aneurysm in a mouse model.
Golub, "Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steriodal anti-inflammatory drug," Journal of Periodontology, vol.
[3] Nonstandard abbreviations: MMP, matrix metalloproteinase; uPA, urokinase-type plasminogen activator; PAI-1, plasminogen activator inhibitor type 1; TIMP-1, tissue metalloproteinase inhibitor type 1; RT-PCR, reverse transcription-PCR; and Cp, crossing point.
Torres-Gonzalez et al., "Proof of concept: matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes," Journal of Inflammation, vol.
Tissue inhibitor of metal loproteinase (TIMP-2): a new member of the metalloproteinase inhibitor family.
This activity can be inhibited by the metalloproteinase inhibitor GM6001, thereby increasing the amount of the cell surface
Their topics include naturally occurring matrix metalloproteinase inhibitors: a group of promising cardioprotective agents, natural products against drug-induced cardiotoxicity, the role of dietary supplements in cardiovascular disease, and the beneficial role of antioxidant molecules with therapeutic potential in cardiac disease.
Mobashery, "Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood-brain barrier opening in rodents: differences in response based on strains and solvents," Brain Research, vol.

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