metalloenzyme


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metalloenzyme

 [mĕ-tal″o-en´zīm]
any enzyme containing tightly bound metal atoms, e.g., the cytochromes.

me·tal·lo·en·zyme

(mĕ-tal'ō-en'zīm),
An enzyme containing a metal (ion) as an integral part of its active structure, for example, cytochromes (Fe, Cu), aldehyde oxidase (Mo), catechol oxidase (Cu), carbonic anhydrase (Zn).

metalloenzyme

An enzyme that contains a metal ion, usually held by co-ordinate-covalent bonds on the amino acid side chains, or bound to a prosthetic group (e.g., heme). The metal ions function like coenzymes, imparting activity to the enzymes.

Examples
Alcohol dehydrogenase (zinc), ascorbic acid oxidase (copper), cytochrome (iron), cytochrome oxidase (copper), glutamate mutase (cobalt), glutathione peroxidase (selenium), urease (nickel), and xanthine oxidase (molybdenum).

me·tal·lo·en·zyme

(mĕ-tal'ō-en'zīm)
An enzyme containing a metal (ion) as an integral part of its active structure; e.g., cytochromes (Fe, Cu), aldehyde oxidase (Mo), catechol oxidase (Cu), carbonic anhydrase (Zn).
References in periodicals archive ?
Over 30% of known enzymes are metalloenzymes, covering all major enzyme classes: oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases.
Enzymes that depend on metal ions as cofactors are of two sorts: enzymes activated by metals and metalloenzymes. As the name implies, in enzymes activated by metals, catalysis is triggered by the presence of a mono- or divalent metal ion on the outside of the protein.
Sandre et al., "Alterations of antioxidant trace elements (Zn, Se, Cu) and related metalloenzymes in plasma and tissues following burn injury in rats," Burns, vol.
The slightly acidic properties of the boronic acid functional groups, combined with the electronegativity tendency from its nitrogen atom, may contribute to the inhibition activity to the [Zn.sup.2+] metalloenzyme pocket [62].
It should prove useful for investigating complexes of a range of other ligand types, as well as for the study of metal-containing biological molecules such as metalloenzymes, in addition to their catalytic activity for important industrial applications.
3.1.8.1) is a metalloenzyme in which four histidine residues coordinate two divalent cations.
KEY WORDS: phenoloxidase, bay scallop, Argopecten irradians, linear-gradient native PAGE, hemocyte, metalloenzyme
It is possible that bisulfite may also lead to further reactive sulfur species via the peroxidase activity of enzymes such as copper,zinc-superoxide dismutase (Cu, Zn-SOD), a metalloenzyme that catalyzes the dismutation of the superoxide anion into [O.sub.2] and hydrogen peroxide ([H.sub.2][O.sub.2]).
Carbonic anhydrase was the first discovered zinc metalloenzyme; other enzymes include: carboxypeptidase, alkaline phosphatase, DNA/RNA polymerase and superoxide dismutase.
Bhasmas, in combination with modern delivery systems, provide new routes to anti-aging via metalloenzyme modulation.
He studied hydrolytic metalloenzyme mechanisms at Columbia University with Ron Breslow as an NSERC post-doctoral fellow.