matrix metalloproteinase 12

(redirected from metalloelastase)

matrix metalloproteinase 12

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
CD40L, GM-CSF, IL-1β, IL-13, MCP-1, M-CSF, PDGF-BB, TNF-α, VEGF.
 
Substrates
Collagen IV; gelatin; elastin and k-elastin; casein; α1-AT; fibronectin; vitronectin; laminin; entactin; proteoglycan monomer; GST-TNF; MBP; fibrinogen; fibrin; plasminogen.
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References in periodicals archive ?
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Shapiro et al., "Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen," The American Journal of Pathology, vol.
Shay et al., "Acute cigarette smokeinduced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice," American Journal of Respiratory Cell and Molecular Biology, vol.
MMP-12 (metalloelastase) is expressed mostly in macrophages and is responsible for their migration.
Yu et al., "Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits," Circulation, vol.
Overall, "Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR + CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: Potential role of the macrophage in terminating polymorphonuclear leukocyte influx," Blood, vol.
Werner et al., "Transforming growth factor-[beta]1 inhibits cytokine-mediated induction of human metalloelastase in macrophages," Journal of Biological Chemistry, vol.
The main role of macrophage metalloelastase (MMP-12) is degradation of elastin.
Yet another study elucidated that a topical, occlusive pre-treatment with 5% vitamin E for 24 hours would provide protection against ultraviolet-caused up-regulated macrophages metalloelastase in skin.24 Others showed that vitamin E had the ability to penetrate into the dermal parts with oxidative stress, and have a positive impact.25,26
(2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
Saarialho-Kere, "Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations," The American Journal of Pathology, vol.