matrix metalloproteinase 12

(redirected from metalloelastase)

matrix metalloproteinase 12

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
CD40L, GM-CSF, IL-1β, IL-13, MCP-1, M-CSF, PDGF-BB, TNF-α, VEGF.
 
Substrates
Collagen IV; gelatin; elastin and k-elastin; casein; α1-AT; fibronectin; vitronectin; laminin; entactin; proteoglycan monomer; GST-TNF; MBP; fibrinogen; fibrin; plasminogen.
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References in periodicals archive ?
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Association between aortic aneurysm and ulcerative colitis: A nationwide taiwanese retrospective cohort study
Shapiro et al., "Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen," The American Journal of Pathology, vol.
Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites
Shay et al., "Acute cigarette smokeinduced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice," American Journal of Respiratory Cell and Molecular Biology, vol.
Dysregulated Functions of Lung Macrophage Populations in COPD
MMP-12 (metalloelastase) is expressed mostly in macrophages and is responsible for their migration.
Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma
Yu et al., "Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits," Circulation, vol.
Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits
MMP-12 is a macrophage metalloelastase that has a role in ECM remodeling processes [6].
Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population
Overall, "Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR + CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: Potential role of the macrophage in terminating polymorphonuclear leukocyte influx," Blood, vol.
Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis
Werner et al., "Transforming growth factor-[beta]1 inhibits cytokine-mediated induction of human metalloelastase in macrophages," Journal of Biological Chemistry, vol.
Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells
The main role of macrophage metalloelastase (MMP-12) is degradation of elastin.
A predictive HQSAR model for a series of Tricycle core containing MMP-12 inhibitors with dibenzofuran ring
Yet another study elucidated that a topical, occlusive pre-treatment with 5% vitamin E for 24 hours would provide protection against ultraviolet-caused up-regulated macrophages metalloelastase in skin.24 Others showed that vitamin E had the ability to penetrate into the dermal parts with oxidative stress, and have a positive impact.25,26
Vitamin E and its clinical challenges in cosmetic and reconstructive medicine with focus on scars; a review
(2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
Serum levels of matrix metalloproteinase 3 (stromelysin 1) for monitoring synovitis in rheumatoid arthritis
Saarialho-Kere, "Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations," The American Journal of Pathology, vol.
Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn's Disease and Ulcerative Colitis

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