Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage
metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Shapiro et al., "Role of
metalloelastase in a model of allergic lung responses induced by cockroach allergen," The American Journal of Pathology, vol.
Shay et al., "Acute cigarette smokeinduced connective tissue breakdown requires both neutrophils and macrophage
metalloelastase in mice," American Journal of Respiratory Cell and Molecular Biology, vol.
MMP-12 (
metalloelastase) is expressed mostly in macrophages and is responsible for their migration.
Yu et al., "Macrophage
metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits," Circulation, vol.
MMP-12 is a macrophage
metalloelastase that has a role in ECM remodeling processes [6].
Overall, "Macrophage-specific
metalloelastase (MMP-12) truncates and inactivates ELR + CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: Potential role of the macrophage in terminating polymorphonuclear leukocyte influx," Blood, vol.
Werner et al., "Transforming growth factor-[beta]1 inhibits cytokine-mediated induction of human
metalloelastase in macrophages," Journal of Biological Chemistry, vol.
The main role of macrophage
metalloelastase (MMP-12) is degradation of elastin.
Yet another study elucidated that a topical, occlusive pre-treatment with 5% vitamin E for 24 hours would provide protection against ultraviolet-caused up-regulated macrophages
metalloelastase in skin.24 Others showed that vitamin E had the ability to penetrate into the dermal parts with oxidative stress, and have a positive impact.25,26
(2-4) Secreted-type MMPs can be classified into 6 subgroups according to their substrate specificity and structural differences (2): (1) collagenases, including tissue collagenase (MMP1), neutrophil collagenase (MMP8), and collagenase 3 (MMP13); (2) gelatinases, such as gelatinase A (MMP2) and gelatinase B (MMP9); (3) stromelysins, including stromelysin 1 (MMP3) and stromelysin 2 (MMP-10); (4) matrilysins, such as matrilysin 1 (MMP7) and matrilysin 2 (MMP26); (5) furin-activated MMPs, including stromelysin 3 (MMP-13) and epilysin (MMP 28); and (6) other MMPs such as
metalloelastase (MMP12), MMP19, enamelysin (MMP-20), MMP21, and MMP-27.
Saarialho-Kere, "Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage
metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations," The American Journal of Pathology, vol.