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a type of receptor that is linked to intracellular production of 1,2-diacylglycerol and inositol 1,4,5-trisphosphate.
[metabolism + G. tropē, turning, inclination, + -ic]
metabotropic receptor A type of G protein-coupled membrane receptor indirectly linked to ion-channels through signal transduction, typically by G protein signalling. In contrast to ionotropic receptors—which form ion channels and when activated open those channels to ions such as Na+, K+ or Cl-, allowing their flow in or out of cells—metabotropic receptors do not form ion channels. Metabotropic receptor activation triggers intracellular events that lead to the production of second messengers, which influence ionotropic receptors and ion channel opening.