metabotropic receptor

Related to metabotropic receptor: Metabotropic glutamate receptor

me·tab·o·tro·pic re·cep·tor

a type of receptor that is linked to intracellular production of 1,2-diacylglycerol and inositol 1,4,5-trisphosphate.

[metabolism + G. tropē, turning, inclination, + -ic]

metabotropic receptor

A type of G protein-coupled membrane receptor indirectly linked to ion-channels through signal transduction, typically by G protein signalling. In contrast to ionotropic receptors—which form ion channels and when activated open those channels to ions such as Na+, K+ or Cl-, allowing their flow in or out of cells—metabotropic receptors do not form ion channels. Metabotropic receptor activation triggers intracellular events that lead to the production of second messengers, which influence ionotropic receptors and ion channel opening.

References in periodicals archive ?

Necessary additional research should make use of parallel recording of behavior and bioelectric brain activity as well as of the discoveries of molecular biology in order to further better understanding of the participation of ionotropic and metabotropic receptors of inhibitory GABA mediators in learning.

The effects of agonists of ionotropic [GABA.sub.A] and metabotropic [GABA.sub.B] receptors on learning

Each neuron carries receptors for both excitatory and inhibitory neurotransmitters on its surface; moreover, some of the signals will be mediated through ionotropic receptors and induce fast responses whereas others will be mediated through metabotropic receptors and trigger slow responses.

How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective

AMPA, NMDA, and metabotropic receptors have been found in the vestibular nuclei.

Vertigo and motion sickness. Part I: vestibular anatomy and physiology

Thirteen chapters deal with N-methyl-n-aspartate (NMDA) receptors, 8 with 2-amino-3-hydroxy-5-methyl-4-isoxazole propicnic acid (AMPA) receptors, 6 with kainate receptors, and 6 with metabotropic receptors.

Excitatory Amino Acids: Ten Years Later

The modulation of glutamatergic ionotropic or metabotropic receptors is shown in Table 4.

Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine

Glutamate is the primary excitatory neurotransmitter in the CNS of vertebrates, activating both ionotropic mad metabotropic receptors (1).

Development and characterization of a self-referencing glutamate-selective Micro-biosensor

Binding of glutamate to metabotropic receptors involves guanosine nucleotide-binding protein (G-protein).

Secondary Mechanisms in Traumatic Brain Injury: A Nurse's Perspective

It has been previously shown that the intrinsic biochemical steps of STM include the activation of glutamate NMDA, AMPA and metabotropic receptors in the CAI region of the hippocampus, and that STM is activated by AMPA, but not NMDA receptors in the entorhinal cortex (Izquierdo et al.

(--)-Linalool, a naturally occurring monoterpene compound, impairs memory acquisition in the object recognition task, inhibitory avoidance test and habituation to a novel environment in rats

44] These metabotropic receptors are both autoreceptors and heteroreceptors that mediate the release of 5-HT and other neurotransmitters such as acetylcholine and glutamate.

Serotonergic receptors as targets for pharmacotherapy

Among the three known classes of GABA receptors, GABAa and GABAc ionotropic receptors (ion channels), and GABAb metabotropic receptors (G protein-coupled receptors), the GABAa receptor is one of the most promising targets for a wide range of CNS-related diseases including anxiety, irritability, insomnia, and depression (Mohler et al.

Noni as an anxiolytic and sedative: a mechanism involving its gamma-aminobutyric acidergic effects