Deletion of the type 2 metabotropic glutamate receptor
increases heroin abuse vulnerability in transgenic rats.
Some studies have reported that the single nucleotide polymorphism (SNP) of metabotropic glutamate receptor
7 (GRM7) gene is related to ARHI [10-13].
According to the company, the glutamate receptors, in particular the metabotropic glutamate receptor
1 (GRM1), are expressed on several tumors and plays a critical role in tumor metabolism.
Therapeutic potential of metabotropic glutamate receptor
Morgan et al., "Central amygdala metabotropic glutamate receptor
5 in the modulation of visceral pain, "Journal of Neuroscience, vol.
Cenci, "Antagonism of metabotropic glutamate receptor
type 5 attenuates L-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease," Journal of Neurochemistry, vol.
Andree, "The inhibition of glycogen synthase kinase 3[beta] by a metabotropic glutamate receptor
5 mediated pathway confers neuroprotection to A[beta] peptides," Journal of Neurochemistry, vol.
Global Markets Direct's, 'Metabotropic Glutamate Receptor
3 (mGluR3 or GRM3 or GPRC1C or MGLUR3) - Pipeline Review, H1 2016', provides in depth analysis on Metabotropic Glutamate Receptor
3 (mGluR3 or GRM3 or GPRC1C or MGLUR3) targeted pipeline therapeutics.
(1996) Presynaptic calcium current modulation by a metabotropic glutamate receptor
. Science 274, 594-597.
Among pipeline products, the report particularly details pipeline programs targeting the following factors: LRRK2, progranulin, glial cell-derived neurotrophic factor, cerebral dopamine neurotrophic factor, tyrosine receptor kinase B, mesencephalic astrocyte-derived neurotrophic factor, metabotropic glutamate receptor
, DJ-1, C-jun-N-terminal kinases, reactive oxygen species, heat shock proteins, heat shock transcription factor, growth hormone secretagogue receptor, protein phosphasate 2A, and cytochrome P450 2D6.
This allows another protein, mGluRS Metabotropic Glutamate Receptor
, to function unchecked resulting in over activity in the brain.
Conn, "Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor
, mGluR5, in native and recombinant systems," Annals of the New York Academy of Sciences, vol.