metabotropic


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metabotropic

adjective Referring to production of a metabolite or intracellular messenger related to receptor interactions.

metabotropic

(mĕ-tab″ŏ-trō′pik, -trop′) [ metabo(lism) + -tropic]
Linked to G proteins and influenced by metabolism; said of specific cell surface receptors.
References in periodicals archive ?
Effect of novel allosteric modulators of metabotropic glutamate receptors on drug self-administration and relapse: a review of preclinical studies and their clinical implications.
Some studies have reported that the single nucleotide polymorphism (SNP) of metabotropic glutamate receptor 7 (GRM7) gene is related to ARHI [10-13].
Parsons, "Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of [beta]-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices," Neuropharmacology, vol.
[alpha]KG: [alpha]-ketoglutarate; D-Ser: D-Serine; GS: glutamine synthase; EAAT: excitatory amino acid transporter; EETs: epoxyeicosatrienoic acids; Glut-: glutamate; Gln: glutamine; GLS: glutaminase; mGluRI: group I metabotropic glutamate receptors; PG: prostaglandins; Pyr: pyruvate; TCA: tricarboxylic acid cycle.
These findings gave rise to the metabotropic deficit hypothesis [11], according to which the absence of neurotrophins can lead to the development of metabolic diseases [12].
We evaluated the circulating levels of the neuropeptide neurotensin and the metabotropic BDNF, which are neuroendocrine factors expressed in adipose tissue possibly involved in modulating inflammation and mucosal barrier integrity.
N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans.
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice.
According to the company, the glutamate receptors, in particular the metabotropic glutamate receptor 1 (GRM1), are expressed on several tumors and plays a critical role in tumor metabolism.
The role played by glutamate in the mechanism and progression of PD via various ionotropic and metabotropic receptor types in the basal ganglia motor loop has been extensively investigated.
The main mechanism of action of DMT appears to partial agonism on serotonergic 2A ([5-HT.sub.2A]) receptors expressed on layer V cortical neurons, a process that also seems to involve metabotropic glutamate receptors (mGluR) (7,8).