In addition, owing to the close relationship among Class C GPCRs, the enhanced knowledge of the mechanism of action of allosteric modulators for metabotropic
glutamate receptors will enable the design of both negative and positive allosteric modulators by providing a template for homology modeling of other Class C GPCRs.
Phase II and III testing is also under way with Eli Lilly's LY-2140023, an agent that targets metabotropic
glutamate type 2/3 (mGluR2/3) receptors.
Urothelium also expresses a host of other metabotropic
and ionotropic receptors such as TRPV1 and TRPM8, whose functional role is yet to be confirmed.
Mood disorders: Regulation by metabotropic
1989), GRM3 (glutamate receptor, metabotropic
3) (Xu et al.
There also are three families of G protein-coupled glutamate receptors, and these are denoted as group I, II, and III metabotropic
glutamate receptors (mGluR I--III), based on their functional properties and effects on neuronal function.
While there are different types of receptors at the synapse, abnormally high signalling through one particular class -- the group 1 metabotropic
glutamate receptor -- is implicated in many of the symptoms seen in FXS.
Modulation of the neuronal dopamine transporter activity by the metabotropic
glutamate receptor mGIuR5 in rat striatal synaptosomes through phosphorylation mediated processes.
glutamate receptors contribute to habituation of a simple odor-evoked behavior.
The rising of extracellular glutamate levels is responsible for the constant activation of metabotropic
and ionotropic glutamate receptors thus elevating [Na.
Expression pattern and pharmacology of the rat type IV metabotropic
receptors , responding to the same neurotransmitters, set off chemical cascades in the receiving nerve cells, so-called "second messenger" systems, chains of chemical processes activating synthesis of neurotransmitters, of receptors and of modulators, changing the reactivity of the nerve cell and of the system it subserves.