metabotropic


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metabotropic

adjective Referring to production of a metabolite or intracellular messenger related to receptor interactions.

metabotropic

(mĕ-tab″ŏ-trō′pik, -trop′) [ metabo(lism) + -tropic]
Linked to G proteins and influenced by metabolism; said of specific cell surface receptors.
References in periodicals archive ?
In addition, owing to the close relationship among Class C GPCRs, the enhanced knowledge of the mechanism of action of allosteric modulators for metabotropic glutamate receptors will enable the design of both negative and positive allosteric modulators by providing a template for homology modeling of other Class C GPCRs.
Phase II and III testing is also under way with Eli Lilly's LY-2140023, an agent that targets metabotropic glutamate type 2/3 (mGluR2/3) receptors.
Urothelium also expresses a host of other metabotropic and ionotropic receptors such as TRPV1 and TRPM8, whose functional role is yet to be confirmed.
Mood disorders: Regulation by metabotropic glutamate receptors.
There also are three families of G protein-coupled glutamate receptors, and these are denoted as group I, II, and III metabotropic glutamate receptors (mGluR I--III), based on their functional properties and effects on neuronal function.
While there are different types of receptors at the synapse, abnormally high signalling through one particular class -- the group 1 metabotropic glutamate receptor -- is implicated in many of the symptoms seen in FXS.
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGIuR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Cortical metabotropic glutamate receptors contribute to habituation of a simple odor-evoked behavior.
The rising of extracellular glutamate levels is responsible for the constant activation of metabotropic and ionotropic glutamate receptors thus elevating [Na.
So-called metabotropic receptors , responding to the same neurotransmitters, set off chemical cascades in the receiving nerve cells, so-called "second messenger" systems, chains of chemical processes activating synthesis of neurotransmitters, of receptors and of modulators, changing the reactivity of the nerve cell and of the system it subserves.