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Depending on the variant, CYP3A5 proteins can affect how the body metabolizes certain environmental contaminants, including aflatoxins, compounds produced by molds and found in some animal feeds and peanuts, Schuetz says.
Individuals with a common genetic variation may not metabolize certain drugs as readily as those without the mutation, researchers report in the April 2001 Nature Genetics.
Research from the late 1980s had shown that CYP3A5 helps metabolize drugs, yet is not in the tissues of some people.
The enzyme metabolizes about 60 percent of all drugs, making them more easily soluble in water so they can be flushed out of the body.
The current study extends our earlier studies with alachlor and demonstrates that rat liver microsomes metabolize acetochlor and metolachlor to CMEPA (0.
If humans are able to metabolize each of these herbicides to the DNA-reactive metabolite, then the risk of these herbicides should be combined into the same risk cup.
Codeine's analgesic properties stem mainly from the body's ability to metabolize it into morphine, a much more potent opiate, says Alastair J.
Noting that the body metabolizes amonafide and caffeine similarly, Mark J.
Oncologists using the experimental cancer drug amonafide face a particularly precarious balancing act, because different people metabolize the drug in different ways.
The surprising findings show elevated risk in women who may have inherited a flawed enzyme that poorly metabolizes a certain dairy sugar -- a risk that grows with the amount of dairy products consumed.
The new findings indicate some women are genetically predisposed to ovarian cancer because they produce a flawed version of galactose-1-phosphate uridyl-transferase, the enzyme that metabolizes galactose.
In the United States and other industrialized countries, he notes, glucose tolerance -- the rate at which the body metabolizes excess sugar -- also declines with age.