Some of the pollutants whose concentrations increased in shrinking fat stores--but none that decreased--are typically metabolized
by an enzyme that may be suppressed during hibernation, the researchers found.
Other medications that are metabolized
by this isoenzyme include haloperidol, olanzapine, thioridazine, tacrine, amitriptyline, imipramine, clomipramine, warfarin, propranolol, methadone, verapamil, and theophylline.
Because folate is routinely measured in the ongoing NHANES cycles and speciated arsenic measurements have begun in the same samples, the role of one-carbon metabolism should certainly be considered in interpreting results for arsenic and other similarly metabolized
chemicals for future editions of the CDC's National Report on Human Exposure to Environmental Chemicals (CDC 2001, 2003b).
If the drugs are metabolized
by the same or similar pathways, you can expect some type of interaction," the pharmacologist said.
So instead the researchers concentrated on the compounds that enter the bloodstream after quercetin is ingested, absorbed and metabolized
When the research team bathed each cell sample in a high-fat broth, the cells metabolized
the fat with about the same efficiency as the person who had given them did.
As chlorines are removed by bioremediation, the less-chlorinated products could be more readily metabolized
by many species exposed to the bioremediated material.
When arsenic is metabolized
, it takes on new chemical identities that vary widely in their toxicity.
The non-Hispanic white volunteers typically metabolized
the drug 32 percent more rapidly than the volunteers of other ethnic groups did.
In general, organophosphorus pesticides are metabolized
by these routes, and about 75% of the 40 or so organophosphorus pesticides that are registered by the U.S.
Last year, a study in the Journal of the American Medical Association (JAMA) considered whether various drugs are metabolized
by one or more enzymes that have genetic variants that result in unusually slow breakdown.
CYP2D6 codes for enzymes that metabolize chemicals such as medications that target the central nervous system (including various antidepressants, stimulants, and codeine--all drugs with different chemical structures), drugs of abuse, neurotoxicants, procarcinogens (substances that become carcinogenic only when metabolized
into more reactive compounds), and even the body's own neurotransmitters.