metaboliser


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metaboliser

A person who metabolises; that which metabolises, or helps metabolise, a substance.
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References in periodicals archive ?
(3) For drugs inactivated by the CYP enzymes, poor metabolisers will be slow to clear the drug and risk toxicity, while ultrafast metabolisers will clear the drug too rapidly and may not achieve therapeutic plasma concentrations (see box 1, p22).
Up to 10 percent of people of European descent, and three per cent of Asians, Africans and Maori and Pacific peoples, are poor metabolisers at CYP2D6.
"This means that this ratio is highly accurate at detecting 'poor metabolisers' who need to be switched to another painkiller," he said.
Varin and his colleagues believe that the ODT/tramadol ratio gives doctors a new tool to identify "poor metabolisers" in the clinic.
Fast metabolisers completed the course 7% faster, on average, after ingesting caffeine than after the placebo.
There only appear to be about 10% of the Caucasion population who are poor Debrisoquine or Methoxyphenamine metabolisers. It is the ratio of the excretion of drug, O-demethyl and N-demethyl metabolites in urine (scheme 4) for eight hours after dosing which allows categorization of metabolisers.
The potential study participants were genotyped by PAREXEL to identify nearly 400 poor metabolisers of Cytochrome P450 2D6 (CYP2D6), an enzyme involved in the metabolism of drugs.