He was part of a team that carried out a major study of 3.5 million people, led by the University of Birmingham and published in the Journal of the American College of Cardiology last year, which found "metabolically
healthy obese" people were considerably more at risk than non-obese people of developing potentially fatal conditions.
Dannenberg says that he and his colleagues have preliminary evidence that the risk of heart disease is also higher in metabolically
obese postmenopausal women.
But as specialists have pointed out, there is currently no clear definition of metabolically
healthy obesity, so different studies investigating the specifics of this condition may each describe it differently.
In previous analyses, we created four categories combining metabolic status and BMI categories: MHO (BMI > 30 kg/[m.sup.2] with metabolic health), metabolically
unhealthy obese (BMI > 30 kg/[m.sup.2] and >2 of the metabolic criteria), metabolically
healthy nonobese (BMI < 30 kg/[m.sup.2] with metabolic health), and metabolically
unhealthy nonobese (BMI < 30 kg/[m.sup.2] and >2 of the metabolic criteria) .
Individuals who were overweight but metabolically
healthy had a 30% increased risk of ischemic heart disease, 11% increased risk of heart failure, and the same risk of cerebrovascular disease as normal-weight, healthy individuals.
"In our study, we had unprecedented statistical power to examine body size phenotypes by the number of metabolic abnormalities, potentially reflecting several definitions of the 'metabolically
healthy' phenotype in relation to a range of CVD events," lead author and epidemiologist Dr Rishi Caleyachetty said.
Some people are 'TOFI' (thin on the outside, fat on the inside), while some are MHO (metabolically
Participants were separated by subgroups of metabolically
healthy obese (MHO) individuals, defined as having none of four National Cholesterol Education Program (NCEP) metabolic syndrome components after excluding waist circumference.
Unique determinants that differentiate MHO and metabolically
abnormal obesity (MAO) are largely unknown.
The microbes, which the scientists plucked from clouds above the Auvergne region of France, were known to be metabolically
active in clouds, but their diets were a mystery.
Scientists and engineers in biochemistry, biotechnology, and related fields survey developments and prospects for producing biofuel molecules such as hydrogen, methane, ethanol, butanol, higher chain alcohols, isoprenoids, and fatty acid derivatives by metabolically
engineered microbes such as bacteria, yeast, and microalgae.
They are defined as metabolically
obese normal weight individuals (MONW).