Since the definition of metabolome, almost 20 years ago, different terms related to metabolite quantification and quality measurement have been defined, including metabolome mapping, metabolic fingerprinting, metabolic profiling
, metabolic footprinting, and metabolic target analysis to untargeted metabolic profiling
In serum and urine metabolic profiling
, COPD subjects with no exacerbation clustered separately from patients with respiratory failure requiring NIPPV due to AECOPD, CHF, or PNA (Figures 1 and 2).
Global metabolic profiling
, called metabolomics, has the potential to identity novel biomarkers that could help elucidate OA diagnosis and could function as targets for the development of new drugs aimed at treatment of OA (26).
To facilitate this approach, we also introduce the concept of magnetic resonance mass spectrometry (MRMS) for rapid metabolic profiling
. MRMS combines the ultra-high performance of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry with the advantages of matrix assisted laser desorption ionization (MALDI) for rapid, straightforward profiling analysis.
Based in Helsinki, Nightingale Health is a metabolic biomarker analysis company and, through the use of its platform, the company is able to provide scalable metabolic profiling
for various areas of medicine.
distinguishes youth patient group disease states
Finally, as is the case for whole genome sequencing, ethical and legal issues arise from nontargeted metabolic profiling
. For instance, data protection is crucial, because state-of-the art metabolomics is able to reveal xenobiotics in the blood of research participants (e.g., antidepressants and recreational drugs).
"And they've carried that forward by combining it with state-of-the-art technology in such areas as telemedicine, metabolic profiling
, and practice management.
Using a technique known as metabolic profiling
, levels of 363 metabolites involved in most human biochemical pathways were measured in all participants.
Huang et al., "Malignancy-associated metabolic profiling
of human glioma cell lines using 1H NMR spectroscopy," Molecular Cancer, vol.