metabolic disease

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Related to metabolic disorder: diabetes, metabolic syndrome

metabolic

 [met″ah-bol´ik]
pertaining to or of the nature of metabolism.
metabolic disease a disease caused by some defect in the chemical reactions of the cells of the body.
metabolic syndrome a combination including at least three of the following: abdominal obesity, hypertriglyceridemia, low level of high-density lipoproteins, hypertension, and high fasting plasma glucose level. It is associated with an increased risk for development of diabetes mellitus and cardiovascular disease.

met·a·bol·ic dis·ease

generic term for disease caused by an abnormal metabolic process. It can be congenital, due to inherited enzyme abnormality, or acquired, due to disease of an endocrine organ or failure of function of a metabolic important organ such as the liver.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

acute abdomen

A relatively nonspecific symptom complex, in which a Pt is first seen in a 'toxic' state, complaining of incapacitating abdominal pain, variably accompanied by fever, and leukocytosis; AA may also be defined as an acute intra-abdominal inflammatory process that may require surgical intervention; appendicitis is the most common cause of an AA; nearly 100 other conditions may present in a similar fashion, in particular, ruptured ectopic pregnancy in a fallopian tube, ruptured acute diverticulitis and acute mesenteric lymphadenitis.
Acute abdomen etiology
Infection
Amebiasis, hepatitis, falciparum malaria, pneumococcal pneumonia, rheumatic fever, salmonella gastroenteritis, staphylococcal toxemia, syphilis in 'tabetic crisis,' trichinosis, TB, typhoid fever, viral enteritides, herpes zoster, infectious mononucleosis, Whipple's disease
Inflammation
Appendicitis, cholangitis, cholecystitis, Crohn's disease, diverticulitis, gastroenteritis, hepatitis, SLE, mesenteric lymphadenitis, pancreatitis, peritonitis due to organ perforation, perinephric abscesses, pyelonephritis, ulcerative colitis, intestinal obstruction, rheumatoid arthritis, polyarteritis nodosa, Henoch-Schönlein disease
Intoxication
Black widow spider bite, heavy metals, mushrooms
Ischemia
Renal infarction, mesenteric arterial thrombosis
Malignancy
Pain due to organ infarction, Hodgkin's disease ('classically' associated with alcohol ingestion), leukemia, lymphoproliferative disorders
Metabolic disease
Adrenal insufficiency (Addisonian crisis), DKA, familial hyperlipoproteinemia, familial Mediterranean fever, hemochromatosis, hereditary angioneurotic edema, hyperparathyroidism, hyperthyroidism, acute intermittent porphyria, uremia, substance abuse withdrawal
Ob/Gyn
Twisted ovarian cyst, ectopic pregnancy, endometriosis, PD
Referred pain
Pneumonia, MI, pleuritis, pericarditis, myocarditis, hematomata of the rectal muscle, renal colic, peptic ulcer, nerve root compression
Trauma
Perforation/rupture–aortic aneurysm, spleen, bladder

met·a·bol·ic dis·ease

(met-ă-bolik di-zēz)
Generic term for disease caused by an abnormal metabolic process; can be congenital, due to inherited enzyme abnormality, or acquired, due to disease of an endocrine organ or failure of function of a metabolic important organ.
References in periodicals archive ?
In the last few years, there has been a growing interest in the role of miRNAs in the development of obesity-induced metabolic disorder. These miRNAs play important roles in physiologic and pathophysiological conditions which participate in cell differentiation, proliferation, apoptosis, hematopoiesis, limb morphogenesis, and important metabolic pathways, such as insulin secretion, triglyceride and cholesterol biosynthesis, and oxidative stress [12,13].
Underlying aetiology was metabolic disorders 10 (13.5%), cryptogenic 9(12.1%), hepatitides 5(6.7%), biliary atresia 4(5.4%) and vanishing bile duct syndrome 1(1.3%).
An abnormal screening result for metabolic disorders requires follow-up, diagnosis, and management.
Amgen also announced it has signed a multifaceted agreement with Biovitrum AB, Stockholm Sweden, under which Amgen receives exclusive rights to develop and commercialize Biovitrum's small molecule 11b-HSD1 enzyme inhibitors for the treatment of metabolic disorders and certain other medical disorders.
'I can find considerable evidence that points in the direction of a metabolic disorder, which is compatible with the picture that occurred in all three cases.
Professor Fleming said that based on the evidence he had available at least one of those deaths seemed compatible with the view that there was a metabolic disorder within the family which could have been inherited by Trupti Patel.
Newborn screening also offers a simple, inexpensive way of determining whether a baby has a metabolic disorder that, if left untreated, could result in permanent neurological or developmental damage, even death.
The first two products authorised under this incentive scheme are for the treatment of Fabry disease, a rare and inherited metabolic disorder affecting less than 5,000 patients world-wide, and just 1 per 400,000 people in the EU.
Researchers from The University of Texas Southwestern Medical Center in Dallas reported what appear to be the first cases of a metabolic disorder called rhabdomyolysis resulting from a drug interaction between protease inhibitors and certain statins.
For this report, a pediatric geneticist and a developmental pediatrician independently reviewed medical data from MADDSP and identified a subset of children for whom the primary etiology of their developmental disability appeared to be a metabolic disorder.
In a bizarre twist of fate, her sentence was overturned when researchers discovered that her second son, born in prison, suffered from a metabolic disorder that had probably caused her first son's death from acidosis.
Amicus announced a major collaboration with the gene therapy program in the Perelman School of Medicine at the University of Pennsylvania, or Penn, to pursue research and development of novel gene therapies for Pompe disease, Fabry disease, CDKL5 deficiency and one additional undisclosed rare metabolic disorder. This relationship will combine Amicus' protein engineering and glycobiology expertise with Penn's adeno associated virus, or AAV, gene transfer technologies to develop AAV gene therapies designed for optimal cellular uptake, targeting, dosing, safety and manufacturability.