metabolic disease


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Related to metabolic disease: Metabolic Bone Disease

metabolic

 [met″ah-bol´ik]
pertaining to or of the nature of metabolism.
metabolic disease a disease caused by some defect in the chemical reactions of the cells of the body.
metabolic syndrome a combination including at least three of the following: abdominal obesity, hypertriglyceridemia, low level of high-density lipoproteins, hypertension, and high fasting plasma glucose level. It is associated with an increased risk for development of diabetes mellitus and cardiovascular disease.

met·a·bol·ic dis·ease

generic term for disease caused by an abnormal metabolic process. It can be congenital, due to inherited enzyme abnormality, or acquired, due to disease of an endocrine organ or failure of function of a metabolic important organ such as the liver.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis

acute abdomen

A relatively nonspecific symptom complex, in which a Pt is first seen in a 'toxic' state, complaining of incapacitating abdominal pain, variably accompanied by fever, and leukocytosis; AA may also be defined as an acute intra-abdominal inflammatory process that may require surgical intervention; appendicitis is the most common cause of an AA; nearly 100 other conditions may present in a similar fashion, in particular, ruptured ectopic pregnancy in a fallopian tube, ruptured acute diverticulitis and acute mesenteric lymphadenitis.
Acute abdomen etiology
Infection
Amebiasis, hepatitis, falciparum malaria, pneumococcal pneumonia, rheumatic fever, salmonella gastroenteritis, staphylococcal toxemia, syphilis in 'tabetic crisis,' trichinosis, TB, typhoid fever, viral enteritides, herpes zoster, infectious mononucleosis, Whipple's disease
Inflammation
Appendicitis, cholangitis, cholecystitis, Crohn's disease, diverticulitis, gastroenteritis, hepatitis, SLE, mesenteric lymphadenitis, pancreatitis, peritonitis due to organ perforation, perinephric abscesses, pyelonephritis, ulcerative colitis, intestinal obstruction, rheumatoid arthritis, polyarteritis nodosa, Henoch-Schönlein disease
Intoxication
Black widow spider bite, heavy metals, mushrooms
Ischemia
Renal infarction, mesenteric arterial thrombosis
Malignancy
Pain due to organ infarction, Hodgkin's disease ('classically' associated with alcohol ingestion), leukemia, lymphoproliferative disorders
Metabolic disease
Adrenal insufficiency (Addisonian crisis), DKA, familial hyperlipoproteinemia, familial Mediterranean fever, hemochromatosis, hereditary angioneurotic edema, hyperparathyroidism, hyperthyroidism, acute intermittent porphyria, uremia, substance abuse withdrawal
Ob/Gyn
Twisted ovarian cyst, ectopic pregnancy, endometriosis, PD
Referred pain
Pneumonia, MI, pleuritis, pericarditis, myocarditis, hematomata of the rectal muscle, renal colic, peptic ulcer, nerve root compression
Trauma
Perforation/rupture–aortic aneurysm, spleen, bladder

met·a·bol·ic dis·ease

(met-ă-bolik di-zēz)
Generic term for disease caused by an abnormal metabolic process; can be congenital, due to inherited enzyme abnormality, or acquired, due to disease of an endocrine organ or failure of function of a metabolic important organ.
References in periodicals archive ?
Specifically, the metabolic diseases of muscle interfere with chemical reactions involved in drawing energy from food.
RIVM, the Ministry of Health Ministry of Health, Welfare and Sport therefore advised positively to add these metabolic diseases by October 1, 2019 to the heel prick screening.
Obesity is a global healthcare issue that is associated with an increased risk of serious metabolic diseases, including cardiovascular disease, Type 2 diabetes, hypertension, stroke, dyslipidemia, and osteoarthritis.
The book covers almost all of the tests performed for inherited metabolic diseases, from plasma ammonia to molecular genetic studies, with concise descriptions, making it a handy guide for clinicians.
At present, researchers and physicians tend to measure arterial compliance (a measure of arterial stiffness) in large arteries in relatively advanced stages of metabolic diseases.
High blood pressure and diabetes were the metabolic diseases which contributed significantly to a 2-3 fold increased risk of heart attack and stroke.
The Scottish drugs specialist, which utilises innovative artificial intelligence to drive drug discovery, said that the research collaboration and licence option agreement with Sanofi will focus on metabolic disease.
"This study is one of the largest ever to link sleep problems with important cardiovascular and metabolic diseases. It joins other studies that show that sleep is an important part of health, just like diet and physical activity," said Philip R Gehrman, PhD, CBSM, assistant professor of psychology in the Department of Psychiatry, clinical director of the Penn Medicine Behavioral Sleep Medicine Program, and senior study author.
Contact: Direct questions about scientific and research issues to Salvatore Sechi, Division of Diabetes, Endocrinology, and Metabolic Diseases, NIDDK, 6707 Democracy Blvd, Rm 611, Bethesda, MD 20892-5460 USA, 301-594-8814, fax: 301-480-2688, e-mail: ss24q@nih.gov; direct questions about peer review issues to Francisco O.
The MRL brings together outstanding scientific and clinical researchers to create an international centre of excellence for research into metabolic disease.
The University of Cambridge Metabolic Research Laboratories (MRL) ant its embedded MRC Metabolic Disease Unit investigate the mechanisms through which metabolic health is maintained and how this is disturbed in disease.
Non-alcoholic steatohepatitis is a metabolic disease with no clear disease origin that is quickly becoming a worldwide epidemic.