metabolic activation

metabolic activation

The chemical conversion of a relatively benign substance into a more hazardous one by normal biochemical processes in cells and tissues.
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The team of researchers demonstrated a relationship between the metabolic activation of the tissue and changes in oxygenated and deoxygenated hemoglobin (red blood pigment), measured by means of multispectral optoacoustic tomography (MSOT).
A cofactor supplemented postmitochondrial fraction (prepared in the laboratory from the liver extract of phenobarbital/[beta]-naphthoflavone pretreated rats) metabolic activation system (S9-mix) was freshly prepared for use in all study phases just prior to treatment.
In this study, we present the successful characterization of a cis-enedial intermediate of LIM and the identification of the cytochromes P450 (CYP450) enzymes responsible for the metabolic activation of LIM.
To determine the effects of E2 on cDC metabolism, we chose two biomarkers of metabolic activation of the cDCs, Pdk1, and nitric oxide (NO).
Metabolic activation is relevant to these two common endocrine activities (Jacobs et al., 2008).
The assays were performed with strains of Salmonella Typhimurium TA97a, TA98, TA100, and TA102 in the presence and absence of metabolic activation.
The cytotoxicity of clivorine varied among cells, which might be due to contribution of metabolic activation. As reported, clivorine showed stronger toxicity on mouse hepatocytes than on L-02 cells, as well as other non-hepatic cells, where metabolic activation might not work as efficiently as in hepatocytes (Ji et al., 2005).
Eight to ten dose levels may be tested, as well as vehicle controls, positive mutagens and S9 metabolic activation systems.
The objective of this study was to examine the features of the mushrooms by light microscope and to evaluate the toxicity of two selected wild mushrooms by Ames test in the presence and absence of metabolic activation by using TA98 and TA100 of Salmonella typhimurium bacterial strains.
Modufolin does not require metabolic activation. It has therefore the potential to benefit all patients irrespective of their capacity to activate folates, whereas today's folate-based drugs must be activated by the body.