meta-analysis


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meta-analysis

 [met″ah-ah-nal´ĭ-sis]
any systematic method that uses statistical analysis to integrate the data from a number of independent studies.

meta analysis

A method that uses statistical techniques to combine results from different studies and obtain a quantitative estimate of the overall effect of a particular intervention or variable on a defined outcome—i.e., it is a statistical process for pooling data from many clinical trials to glean a clear answer. Meta-analysis produces a stronger conclusion than can be provided by any individual study.

Cons
Bias, potential for analytical sloppiness, lack of understanding of basic issues, failure to consider major covariates, and overstating the strengths and precision of the results.

meta-analysis

Data synthesis, quantitative overview Data analysis A systematic method that uses statistical techniques for combining results from different studies to obtain a quantitative estimate of the overall effect of a particular intervention or variable on a defined outcome; MA produces a stronger conclusion than can be provided by any individual study. See Cochran Collaboration, Cumulative meta-analysis.

meta-analysis

An attempt to improve the reliability of the findings of medical research by combining and analyzing the results of all discoverable trials on the same subject. In crude terms the advantages are obvious: trials that find against a hypothesis will cancel out the effect of those that find for it. Pooling of raw data is not, however, without statistical hazard and it has become apparent that meta-analysis can introduce its own sources of inaccuracy. The method is currently undergoing refinement.
References in periodicals archive ?
As described previously, (19) 167 meta-analysis articles were identified from 12 major diagnostic pathology journals and 4 major medicine journals through a literature search in PubMed.
To address the problem of heterogeneity within the analyzed meta-analysis, we extracted information when available.
Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies.
Tobler's first meta-analysis (1986), focusing on the content of drug prevention programs, was based on 98 studies published between 1972 and 1984 encompassing 143 program strategies (modalities).
"Network meta-analysis (NMA) can be defined as the simultaneous comparison of multiple competing treatment modalities within the framework of a single statistical model." [1] It is a generalization of pairwise meta-analysis that permits multiple comparisons (three or more treatment groups) in a single analysis.
Goldsmith and his collaborators found that only the cytokine, IL-6, was significantly elevated, compared with healthy controls, for all three illnesses included in the meta-analysis (P < .01 for all).
* The findings of both of these studies support the findings of a 2015 systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts conducted and published by a panel of experts convened by the American Dental Association Council on Scientific Affairs.
Researchers concluded this meta-analysis suggests garlic supplementation is superior to placebo in reducing BP in hypertensive patients, especially in those with high SBP.
The summary receiver operating characteristic (SROC) curve was used to represent the performance of a diagnostic test,[sup.23] based on data from a meta-analysis. The SROC curve included multiple points, and the cut-off points were determined by the maximal value points, which are the value summations of the sensitivity and specificity.[sup.24] The area under the curve (AUC) and an index Q were discussed as potentially useful summaries of the curve.
The coding sheets could hold up to 253 items from each included meta-analysis. Both authors coded all studies independent of each other.
Meta-analysis Journal Alwell and Cobb Career Development (2009) for Exceptional Individuals Bellini, Peters, Remedial and Special Benner, and Education Hopf (2007) Bender and Smith Journal of Learning (1990) Disabilities Benner et al.
Glass (1976) defines meta-analysis as "the statistical analysis of a large collection of analysis results from individual studies for the purpose of integrating the findings.