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see enkephalin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.
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References in periodicals archive ?
Basal release of met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: A microdialysis study of antinociceptive circuits.
In turn, met-enkephalin, leu-enkephalin, [beta]-endorphin, [alpha]-neo-endorphin, dynorphin, and nociceptin/orphanin are opioid peptides.
Individuals genotyped with MET158MET (rs4680) had higher MOR protein expression and lower met-enkephalin concentrations (54).
Stein, "[beta]-Endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis," Annals of the Rheumatic Diseases, vol.
To determine whether metenkephalin plays a major role in cancer-related pain relief, naloxone was used to reverse the antiallodynic effect due to met-enkephalin. Thus, naloxone was injected intraperitoneally 30 min after PMWT had been assessed on day 21 after tumor cell inoculation, and PMWT was measured again.
Additionally, IL-33 can influence the production of met-enkephalin by ILC2s, which can induce the process of "browning" in differentiated adipose cells [10].
Our study used a TENS protocol with a preset frequency of 2 Hz and an intensity of maximal tolerable but short of pain because low frequency high intensity TENS has been reported to induce the release of [beta] endorphin, endomorphin, and met-enkephalin levels [14].
Recently, it was demonstrated that neurons expressing the dopaminergic receptors were immunopositive for the endogenous opioid met-enkephalin [3].
While the cold effect in part may be mediated by IL-4 and its receptor IL-4Ra in the adipocyte precursors, in mature adipose cells a reduction in the IL4Ra is observed and probably this effect may include diverse mediators, including IL-33 and Met-enkephalin [47, 48].
Met-enkephalin is one of the simplest endogenous opioid peptides within the enkephaline family.