messenger RNA


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Related to messenger RNA: DNA, ribosomal RNA

RNA

 
messenger RNA (mRNA) see ribonucleic acid.
ribosomal RNA (rRNA) see ribonucleic acid.
transfer RNA (tRNA) see ribonucleic acid.

mes·sen·ger RNA (mRNA),

(mes'en-jĕr),
the RNA reflecting the exact nucleoside sequence of the genetically active DNA and carrying the "message" of the latter, coded in its sequence, to the cytoplasmic areas where protein is made in amino acid sequences specified by the mRNA, and hence primarily by the DNA; viral RNAs are considered to be natural messenger RNAs.

messenger RNA

n. Abbr. mRNA
The form of RNA that mediates the transfer of genetic information from the cell nucleus to ribosomes in the cytoplasm, where it serves as a template for protein synthesis. It is synthesized from a DNA template during the process of transcription.

messenger RNA

An RNA (ribonucleic acid) molecule which has coding regions and translation signals derived from a gene, carries the reverse template message from DNA, and is required for protein synthesis. mRNA is a nucleic acid intermediate that specifies the amino acid sequence of a polypeptide during translation. Under most circumstances, and in accordance with the so-called central dogma of biology, the message flows from DNA to RNA, which is then translated into protein. DNA is wrapped around proteins (histones in chromatin); the DNA then unwinds, allowing transcription by one of the three RNA polymerases, forming a primary (nuclear) RNA transcript that is then processed to remove the intervening RNA sequences (introns), yielding a mature mRNA molecule. The mature mRNA then passes through nuclear pores into the cytoplasm, where translation into proteins occurs. When a particular mRNA is no longer needed, it is degraded by ribonucleases.

mes·sen·ger RNA

(mRNA) (mes'ĕn-jĕr)
The RNA reflecting the exact nucleoside sequence of the genetically active DNA and carrying the "message" of the latter, coded in its sequence, to the cytoplasmic areas where protein is made in amino acid sequences specified by the mRNA, and hence primarily by the DNA; viral RNA is considered to be natural messenger RNA.

messenger RNA

Commonly written as mRNA, this is the molecule that reads the genetic code from DNA. Before this can happen the double helix must separate into two single strands. One of these carries the same sequence as the mRNA and is called the coding strand. The other is called the template, or antisense, strand and it is this strand that directs the synthesis of the mRNA by complementary base pairing. In RNA the base uracil replaces thymine. The messenger RNA molecule then leaves the cell nucleus and passes out through a nuclear membrane pore to the site of protein synthesis. There the appropriate amino acids are selected and placed in the right order by TRANSFER RNA which, using its anticodons, reads the code on the messenger RNA.

messenger RNA (mRNA)

a single stranded type of POLYNUCLEOTIDE molecule that comprises a sequence of ribonucleotides with the bases ADENINE, GUANINE, CYTOSINE and URACIL. mRNA is transcribed (see TRANSCRIPTION from the DNA and contains the sequence of instructions from which a PROTEIN is translated (see TRANSLATION by the action of RIBOSOMES.
References in periodicals archive ?
Discovered only about eight years ago, riboswitches are short stretches of RNA that reside within the messenger RNAs of proteins involved in a cell's metabolism.
CureVac has more than 17 years of expertise in handling, optimizing and manufacturing messenger RNA technology for medical purposes.
The new information solidified the team's hunch that the particular region where IRP1 binds to the messenger RNA is a potential drug target.
"But when we rehydrated the knockout moss, all of the messenger RNA disappeared within 15 minutes," he added.
Meltzer says that microRNA might be exerting its effects by binding to messenger RNA before it can be translated into proteins that would switch genes on or off.
At Shire, Heartlein discovered and led early development of several of Shire's enzyme replacement therapies and, most recently, discovered and developed Shire's Messenger RNA Therapy technology acquired by RaNA.
When the defective gene is transcribed into a messenger RNA molecule, the expanded repeat section causes the RNA to bind tightly to certain proteins, forming clumps within the muscle cells.
The researchers also checked for a compound, a specific messenger RNA, required for the manufacture of heart-muscle fiber.
"Within the Wnt pathway, we found that CRD-BP binds to and increases the messenger RNA of a cancer-promoting transcription factor called GLI1," Spiegelman said.