mesothelioma panel

mesothelioma panel

A panel of immune markers used to confirm or exclude a mesothelioma, which may be histologically mistaken for an adenocarcinoma.

Mesothelioma panel
Mesothelioma
+ve—CK5/6, calretinin, thrombomodulin, WT-1, D2-40, EMA (membrane and cytoplasmic).
-ve—BerEP4, MOC-31, TTF-1.

Reactive mesothelial cells
+ve—CK 5/6, calretinin, desmin.
-ve—e-cadherin, EMA, p53.
References in periodicals archive ?
He was a reviewer for the World Health Organization/International Association for the Study of Lung Cancer (IASLC) on lung and pleural tumors, and belonged to the core pathology panel for the IASLC and the International Mesothelioma Panel, where he contributed to the 2006 monograph on mesothelioma.
Similarly, none of 23 benign cases stained by the French Mesothelioma Panel had loss of BAP1.
(11-12) Since the late 1990s, the International Mesothelioma Panel has been headed by Francoise Galateau-Salle, MD, of Caen, France, who is also chair of the French Mesothelioma Reference Panel.
The International Mesothelioma Panel recommends that at least 2 mesothelial and 2 carcinoma markers be used in addition to a pancytokeratin.14 None of these antibodies are 100% specific and false positives (which often show less than 10% staining) can occur in either direction.