mesoridazine


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mesoridazine

 [mes″o-rid´ah-zēn]
a phenothiazine used in the form of the besylate salt as an antipsychotic agent.
References in periodicals archive ?
First generation antipsychotics with an increased risk of QTc prolonging include tioridazina (the highest risk), pimozide, droperidole, mesoridazine and haloperidole with intravenous administration (total cumulative dose > 2 mg) and from the second generation sertindole, amisulpride and ziprasidone.
As melperone, mesoridazine, and pimozide are the three drugs missing additional muscarinic, adrenergic, histaminic and even [D.sub.1] action, [55] the comparison of serotonin versus [D.sub.2/4] action is easier.
The distribution of typical and atypical antipsychotic exposures Antipsychotics n % Typical antipsychotics Thioridazine 4 6.1 Chlorpromazine 5 7.6 Mesoridazine 1 1.5 Trifluoperazine 3 4.5 Zuclopenthixol 1 1.5 Haloperidol 1 1.5 Total 15 22.7 Atypical antipsychotics Quetiapine 27 40.9 Risperidone 15 22.8 Olanzapine 8 12.1 Clozapine 1 1.5 Total 51 77.3 Total 66 100.0 Table 3.
Sertindole was never marketed in the US [6]; mesoridazine was marketed in the US but with a warning regarding dose-related QTc prolongation and associated risk of torsade de pointes [6].
Second, we excluded drugs that were unavailable in Taiwan, including pentazocine, trimethobenzamide, amphetamines, guanadrel, mesoridazine, mineral oil, and desiccated thyroid.
Specifically, concerns center around the piperidine phenothiazines (thioridazine and mesoridazine) because of the increased risk of electrocardiographic changes and medication-induced arrhythmias in renal disease due to electrolyte imbalances.
A low-risk drug was prescribed to the rest of the patients (aripiprazole, ziprasidone, haloperidol, fluphenazine, molindone, pimozide, or mesoridazine).
Electrocardiographic evaluation of mesoridazine. Curr Ther Res 1974; 14: 71.
Some of the psychotropic drugs that can possibly cause TdP are listed in Table 5 and include chlorpromazine, haloperidol, pimozide, thioridazine, mesoridazine, and ziprasidone.
Antipsychotic Medications, Generic and Brand Names and Typical Tablet Dosage Generic Name Brand Name Tablet dosage range Atypical Risperidone Risperdal 1-3 mg Olanzapine Zyprexa 2.5-10 mg Clozapine Clozaril 25-100 mg Quetiapine Seroquel 25-200 mg Ziprasidone Geodon 20-60 mg Aripiprazole Abilify 5-15 mg High Potency Haloperidol Haldol 0.5-20 mg Typical Pimozide Orap 2 mg Fluphenazine Prolixin 2.5-10 mg Medium Potency Trifluoperazine Stelazine 1-10 mg Typical Perphenazine Trilafon 2-16 mg Thiothixene Navane 2-20 mg Loxapine Loxitane 5-50 mg Low Potency Molindone Moban 5-100 mg Typical Mesoridazine Serentil 10-100 mg Thioridazine Mellaril 10-200 mg Chlorpromazine Thorazine 10-200 mg Adapted from Wilens (1999) and Li, Pearrow, & Jimerson (2010).
Furthermore, several drugs may produce false positive results for phencyclidine including ketamine, dextromethorphan, diphenhydramine, ibuprofen, imipramine, meperidine, mesoridazine, thioridazine, and venlafaxine (Sena, Kazimi & Wu 2002).
Currently available drugs associated with QT prolongation include most anti-dysthythmics, erythromycin, droperidol, mesoridazine, and methadone.