Mice were divided into four groups of 6 animals each: (1) control normal chow diet; (2) HFD; (3) HFD treated for the last 8 weeks with cobalt protoporphyrin (CoPP) (once/week a dose of 5 mg/100 g, bw); and (4) HFD treated for the last 8 weeks with CoPP and the last 3 weeks with tin mesoporphyrin
(SnMP at a dose of 20 mg/100 g BW), an inhibitor of HO activity (twice/week).
CoPP plus stannous mesoporphyrin
(SnMP), to inhibit HO activity, was administered intraperitoneally three times a week (20mg/kg) for 6 weeks  to ascertain that any effects of CoPP treatment were related to increased HO activity.
In contrast, the metalloporphyrin, chromium mesoporphyrin
, has been shown to increase the myogenic tone only of the small muscular branch of rat femoral arteries and not of large arterial vessels such as the aorta or the femoral artery .
Another molecule, zinc mesoporphyrin
(a synthetic heme analogue with a central zinc of the mesoporphyin macrocycle) causes a dramatic downregulation of the NS5A protein by enhancing its polyubiquitination and proteasome-dependent degradation.
The use of agar, tin protoporphyrin, zinc or tin mesoporphyrin
and herbal products continues to be researched.
On each plate, two lanes were reserved for porphyrin methyl ester calibrators (equal amounts of uroporphyrin, heptacarboxylic porphyrin, hexacarboxylic porphyrin, pentacarboxylic porphyrin, coproporphyrin, and mesoporphyrin
methyl esters; Porphyrin Products).
Abbreviations aP2: Adipocyte protein 2 [beta]-Catenin: Beta-cadherin associated protein C/EBP[alpha]: CCAAT/enhancer binding protein alpha CoPP: Cobalt protoporphyrin IX dichloride FAS: Fatty acid synthase GLUT5: Glucose transporter member 5 HO: Heme oxygenase HO-1: Heme oxygenase isozyme 1, inducible form HO-2: Heme oxygenase isozyme 2, constitutive form MSC: Mesenchymal stem cell NADPH: Nicotinamide adenine dinucleotide phosphate (reduced form) Peg-1/Mest: Paternally expressed gene 1/mesoderm specific transcript PPAR[gamma]: Peroxisome proliferator activated receptor gamma ROS: Reactive oxygen species SnMP: Tin mesoporphyrin
IX dichloride TNF[alpha]: Tumor necrosis factor-alpha Wnt10b: Wingless-type MMTV integration site family, member 10b.
(SnMP) was from Frontier Scientific Inc.
Clinical efficacy studies in humans have been performed only with tin proto- and mesoporphyrin
because their potencies relative to ZnPP were greater (78).
Mixed calibrators of free porphyrins (uroporphyrin I, heptacarboxylic porphyrin I, hexacarboxylic porphyrin I, pentacarboxylic porphyrin I, coproporphyrin I, and mesoporphyrin
IX), deuteroporphyrin, i-urobilin, and stercobilin were purchased from Porphyrin Products.