3,7,8) However, several other non-salivary gland neoplasms harbor this rearrangement, including secretory carcinoma of breast, infantile fibrosarcoma, congenital mesoblastic nephroma
, and some cases of acute myeloid leukemia.
, the most frequent tumour, is a benign, mostly large mesenchymal tumour, which appears as a solid or partially cystic mass, commonly associated with polyhydramnios.
Differentials for a cystic-solid abdominal mass with calcifications in neonates and early infancy include mesoblastic nephroma
, neuroblastoma, gastrointestinal stromal tumors, lymphangiomas, and teratomas.
It is to be noted that these fusions have also been observed in other neoplasms such as acute myeloid leukemia, congenital mesoblastic nephroma
, and fibrosarcoma,  suggesting that the fusion protein has transforming activity in cells of different lineages.
1,2] The ossification and mesenchymal components are similar to mesoblastic nephroma
Cellular mesoblastic nephroma
(infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy.
During the study period of 2005 to 2008 there were virtually no other pediatric age group renal tumours like clear cell sarcoma, mesoblastic nephroma
, multicystic nephroma etc.
30) Interestingly, the same translocation is also associated with other nonepithelial malignancies, including congenital fibrosarcoma, cellular mesoblastic nephroma
, and acute myeloid leukemia.
6) Clear cell sarcoma kidney & congenital mesoblastic nephroma
(CMN) are rare in children.
4] Carpenter and colleagues demonstrated breakpoints in the q13-15 region of chromosome 12 in leiomyomas and congenital mesoblastic nephroma
11) Other than MASC and secretory carcinoma of breast, ETV6NTRK3 fusions have been found in congenital mesoblastic nephroma
, congenital fibrosarcoma, and acute myeloid leukemia.
13: Distribution of cases PATHOLOGIES NO % WILMSTUMOUR 6 21 MESOBLASTIC NEPHROMA
2 7 NEUROBLASTOMA 7 24 EXTRA ADRENAL 1 4 GANGLIONEUROBLASTOMA HEPATOBLASTOMA 3 10 EPITHELOID 1 4 HEMANGIOENDOTHELIOM A HEP HEMANGIOMA 4 14 OVARIAN TERATOMA 2 7 SPL HAMARTOMA 1 3 MCRP TERATOMA 1 3 SACROCOCCYGEAL 2 3 TERATOMA total 30 100 Distribution WT 21% MBN 7% NB 24% GNB 4% HB 10% EHE 4% 14% 7% 3% 3% 3% Note: Table made from pie chart.