Light microscopy reveals PAS positive and eosinophilic nodules with well-defined boundaries that originate from the mesangium
and these have a prevalence of 12-46%.3 Monocytes and macrophages are cells that play an important role in the synthesis and release of proinflammatory and prooxidant cytokines.18
Moderate confluent granular staining of IgA deposits was identified in the mesangium
. Renal interstitial fibrosis was <10%.
The glomerulus embodies the mesangial cells that have cytoplasmic extensions and materials; the mesangium
Mesangio-capillary Glomerulonephritis with deposits of immunoglobulin in capillary wall, sub endothelium and/or mesangium
Accumulation of lipoproteins in the glomerular mesangium
may stimulate matrix production and glomerulosclerosis (8).
What is the significance of CD34 immunostaining in the extraglomerular and intraglomerular mesangium
? Virchows Arch 2008; 453: 321-8.
IgA nephropathy which usually presents as a primary glomerular disorder characterized by episodic hematuria shows deposition of IgA in the mesangium
is also known to occur in association with celiac disease due to the presence of high levels of IgA antibodies against the food antigen, gliadin in these patients .
The frequency of HT in LN class II reinforces the concept that mesangial LN can be considered the beginning of a disease spectrum that starts in the mesangium
and then progresses to involve other parts of the glomerulus.
On immunofluorescence, there was moderately intense staining for IgA in the mesangium
domain in the glomerulus of the kidney consists of mesangium
cells and mesangium
substrates, including type IV collagen.
Based on these experiments, filtration of PBNPs is not possible due to their negative charge and large size; larger PBNPs deposit in the mesangium
while smaller NPs remain inside the peritubular vessels.
On immunofluorescent histology, C3 stain showed glomeruli with finely granular 3+, irregular diffuse staining of capillary walls, and mesangium
(Starry sky pattern) and IgG demonstrated 1-2+ focal segmental, granular capillary wall staining.