mesangial proliferative glomerulonephritis

mes·an·gi·al pro·lif·er·a·tive glo·mer·u·lo·ne·phri·tis

glomerulonephritis characterized clinically by nephrotic syndrome and histologically by diffuse glomerular increases in endocapillary and mesangial cells and in mesangial matrix; in some cases, there are mesangial deposits of IgM and complement.

mes·an·gi·al pro·lif·er·a·tive glo·mer·u·lo·ne·phri·tis

(mes-an'jē-ăl prō-lif'ĕr-ă-tiv glō-mer'yū-lō-nĕ-frī'tis)
Disorder characterized clinically by the nephrotic syndrome and histologically by diffuse glomerular increases in endocapillary and mesangial cells and in mesangial matrix; in some cases, there are mesangial deposits of IgM and complement.
References in periodicals archive ?
Over the past 30 years, the top five types of PGN were immunoglobulin A nephropathy (IgAN; 24.3%), mesangial proliferative glomerulonephritis (MsPGN; 10.5%), membranous nephropathy (MN; 12.6%), minimal change disease (MCD; 9.8%), and focal segmental glomerulosclerosis (FSGS; 4.6%), and the top four types of SGN were lupus nephritis (LN; 8.6%), Henoch-Schonlein purpura glomerulonephritis (4.1%), hepatitis B virus-associated glomerulonephritis (HBV-GN; 2.6%), and diabetic nephropathy (DN; 1.6%).
Most chronic glomerulonephritis involves mesangial proliferative glomerulonephritis (MesPGN), for which the characteristic is an increase of mesangial cells [30].
The final diagnosis was MPO-ANCAassociated necrotizing and crescentic glomerulonephritis on a background of mesangial proliferative glomerulonephritis consistent with class II lupus nephritis (ISN/RPS).
Bowen-Pope, "Proliferating and migrating mesangial cells responding to injury express a novel receptor proteintyrosine phosphatase in experimental mesangial proliferative glomerulonephritis," The Journal of Biological Chemistry, vol.
IgAN, primary IgA nephropathy; HTN, hypertensive nephrosclerosis; MN, membranous nephropathy; MCD, minimal change disease; TIN, tubulointerstitial nephritis; RA, renal amyloidosis; MPGN, mesangial proliferative glomerulonephritis; CrGN, crescentic glomerulonephritis; ATN, acute tubular necrosis; CIN, chronic interstitial nephritis; FSGS, focal segmental glomerular sclerosis.
The elevated excretion of neopterin with urine was also noticed in adults with mesangial proliferative glomerulonephritis [11].
However, according to their report, membranous glomerulonephritis is a rare pathological finding in PGNMID, like mesangial proliferative glomerulonephritis. In the present report, we report a case of membranous glomerulonephritis associated with focal mesangial proliferation with monoclonal IgG deposits.
Predominant histomorpholo- gical patterns were mesangial proliferative nephritis (focal mesangial proliferative nephritis 14 (12.6%) and diffuse mesangial proliferative nephritis 13 (11.7%) End Stage renal disease focal segmental glo- merulosclerosis minimal change disease followed by amyloidosis membranoproliferative glomerulone- phritis membranous glomerulopathy chronic transplant rejection diabetic nephropathy and rapidly progressive glomerulonephritis found on renal biopsy.Conclusion: In adult population mesangial proliferative glomerulonephritis is the leading histopatho- logical entity in our set up followed by end stage renal disease.
Pathology was consistent with collapsing focal segmental glomerulosclerosis (Figures 1 and 2) with diffuse mesangial proliferative glomerulonephritis, consistent with lupus nephritis class II along with tubular degenerative changes.
(19,20) There were six reports of mesangial proliferative glomerulonephritis. This histological finding is usually due to IgA nephropathy or lupus nephritis.
A renal biopsy sample showed endocapillary and mesangial proliferative glomerulonephritis with abundant focal semilunes (Figure 2, panel A).
Mesangial proliferative glomerulonephritis combined with splenic infarction has been reported.[sup][4] As splenic artery is a terminal artery without communicating branch, splenic infarction has a tendency to spontaneous healing.