Cutting edge: calcium/calmodulin-dependent protein kinase type IV is essential for mesangial cell
proliferation and lupus nephritis," The Journal of Immunology, vol.
Microsco-pic examination showed mild focal mesangial cell
Membranoproliferative glomerulonephritis (MPGN) is characterized by profound hypocomplementemia, mesangial cell
proliferation, mesangial interposition, and the deposition of immunoglobulins and complements in the peripheral portion of the nodules (fringe) formed by merging of glomerular capillaries.
26] Heparan sulphate proteoglycan also strongly inhibits mesangial cell
growth, and loss of heparan sulphate has been shown to be an inducer of the mesangial expansion.
Effects of silibinin and antioxidants on high glucose-induced alterations of fibronectin turnover in human mesangial cell
Development of albuminuria and glomerular lesions in normoglycemic B6 recipients of db/db mice bone marrow: the role of mesangial cell
miR-451 negatively regulated the expression of its target gene Ywhaz , which was required for the activation of p38 MAPK signaling, and inhibited glomerular mesangial cell
proliferation in early DN, thus preventing mesangial hypertrophy.
DN is a complex syndrome whose pathogenesis includes loss of podocytes, mesangial cell
hypertrophy, thickening of glomerular basement membrane (GBM) and renal fibrosis (Brosius et al.
Attenuation of mouse mesangial cell
contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.
It also modulates mesangial cell
growth and stimulates the production of fibronectin, types I and IV collagen, and laminin (Ziyadeh, Sharma, Ericksen, & Wolf, 1994).
Glomerular uptake of nucleosomes: evidence for receptor-mediated mesangial cell
4,44) Another effect of amyloid deposition is enhancement of apoptosis, which explains why in the advanced stages of the disease there is significant mesangial cell
deletion, to the point where these cells essentially disappear and only amyloid remains in the mesangium.