merosin


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merosin

The muscle isoform of laminin, which is characterised by high-affinity, Ca2+-dependent binding to alpha-dystroglycan, thereby linking the sarcolemmal membrane to the extracellular matrix.

merosin

A glycoprotein normally found in the basement membrane of muscles; it helps muscle cells adhere to and interact with each other and the extracellular matrix. Deficiencies of merosin produce several rare autosomal recessive forms of muscular dystrophy.
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7] There are 3 subunits that comprise the merosin protein: a2, [sz]1, and a1.
Histochemical markers of hemangiomas, such as GLUT-1, Lewis Y antigen, FcyRII, and merosin have been shown to coincide with those found in placental tissue.
Minimal changes with i(c) Sarcoglycan abnormal IHC deficient i(d) Merosin deficient i(e) Collagen VI deficient i(f) Dysferlin deficient i(g) Caveolin-3 deficient i(h) Emerin deficient i(i) Normal IHC i(j) Nondiagnostic IHC D.
Nina got involved in the cause after family friends Louise and Paul Jaworski were told that their threeyear-old daughter was diagnosed with merosin deficient muscular dystrophy.
Harry, who attends St Mary's Catholic Primary School, has a very rare condition called congenital muscular dystrophy merosin negative which means he will never be able to walk, crawl or stand.
Kate also congratulated wheelchairbound Bethany Woods, 10, who has merosin negative congenital muscular dystrophy, for her rousing performance of the song Rainbow Connection, made famous in The Muppet Movie.
Merosin negative congenital muscular dystrophy associated with extensive brain abnormalities.
Harry Vaughan was diagnosed as suffering from congenital Muscular Dystrophy Merosin Negative shortly after his first birthday.
Hemangiomas are further characterized by cell markers (GLUT-1, merosin, Lewis Y) that are otherwise found only in human placental tissue.
Decreased staining of the laminin [alpha]2-chain (merosin) has been observed in WWS, although patients have been reported with normal amounts of merosin (146, 147).
This form is severe, autosomal recessive on chromosome 6q2 and due to mutations at the laminin alpha 2 chain of merosin, although some secondary cases are linked to chromosome 19q13.
The four antigens that are highly expressed both by infantile hemangioma endothelium and placental chorionic villi are glucose transporter 1 along with Lewis Y, Fc-gammaRII, and merosin.