Mercapturic acid pathway | definition of mercapturic acid pathway by Medical dictionary
mercapturic acid pathway
mer·cap·tu·ric ac·id path·way
a glutathione-dependent pathway for the detoxification of a number of compounds, including arene oxides; an S-substituted glutathione is formed and ultimately converted to a mercapturic acid (an S-substituted N-acetylated l-cysteine), which is excreted; certain leukotrienes are believed to be degraded through this pathway.
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References in periodicals archive
SF is initially metabolised via the mercapturic acid pathway
in vivo, and experiments have shown that over 70% of orally administered SF in humans is eliminated via this pathway within 12-24 hours.
Relevance of the mercapturic acid pathway
. Chem Res Toxicol 8:3-21 (1995).