meprobamate


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meprobamate

 [mĕ-pro´bah-māt, mep″ro-bam´āt]
an antianxiety agent and skeletal muscle relaxant; administered orally.

me·pro·ba·mate

(mĕ-prō'bă-māt mep'brō-bam'āt), Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

meprobamate

(mĕp′rō-băm′āt′, mĕ-prō′bə-)
n.
A bitter white powder, C9H18N2O4, used as a tranquilizer, muscle relaxant, and anticonvulsant.

meprobamate

A potentially addicting agent that blocks spinal interneurons, which has anticonvulsant, anxiolytic, muscle-relaxing, sedative, hypnotic and tranquilising properties.

Adverse effects
Hypotension, depression of brainstem activity, coma, death.
 
Metabolism
Liver; excreted in urine, stool.

Therapeutic range
5–30 µg/mL.
 
Toxic range
> 60 µg/mL.
 
Specimen
Serum.
 
Method
TLC, GC, colorimetry.

meprobamate

Pharmacology A potentially addicting agent with anticonvulsant, anxiolytic, muscle relaxing, sedative, hypnotic, tranquilizing properties that blocks spinal interneurons, depressing brainstem functions, coma, death; may cause hypotension Metabolism Liver; excreted in urine, stool. See Therapeutic drug monitoring.

me·pro·ba·mate

(mĕ-prō'bă-māt) Avoid the misspelling/mispronunciation meprobromate.
An oral anxiolytic with potential for dependency and addiction.

meprobamate

A mildly tranquillizing carbamate drug with muscle-relaxant properties used in combination with painkilling drugs to treat muscle and joint pain. A brand name is Equagesic.

me·pro·ba·mate

(mĕ-prō'bă-māt)
Oral anxiolytic with potential for dependency and addiction.
References in periodicals archive ?
These drugs, shown in Figure 11, include analgesics, tranquilizers, and depressants (opiates, methadone, benzodiazepines, barbiturates, phencyclidine, ethanol, and meprobamate) as well as stimulants (amphetamine and cocaine).
I moved to Maul, Hawaii, in July 1980 and continued to drink burgundy and take meprobamate until 1983, when I checked myself into Scripps Memorial Hospital in La Jolla, Calif., for chemical addiction treatment.
Calcium-channel-blocking agent in the treatment of acute alcohol withdrawal--caroverine versus meprobamate in a randomized double-blind study.
The records reveal that Kennedy took codeine, Demerol and methadone for pain, Ritalin, a stimulant, meprobamate and librium for anxiety barbiturates for sleep, thyroid hormone, and injections of a blood derivative, gamma globulin, presumably to combat infections.
CLASS C: Temazepam, Diazapan, Tranquilisers, Pipradrol, Dextropropoxyphene, Anabolic steroids, Diethylpropion, Meprobamate, Benzodiazepine, Rohypnol.
Drewes has found plenty of chemicals in treated wastewater--an antibiotic, a chemical used in perfume production, the muscle relaxant drug carisoprodol, and its metabolite meprobamate, among others.
Electomyographic comparison of single doses of exercise and meprobamate as to effects of muscular relaxation.
(Nervous breakdown performed its greatest service in the decades between two different drug regimes.) Widely-prescribed tranquilizers began to give doctors new weapons and new appeal; Miltown (Meprobamate) was the first "minor" tranquilizer available for anxiety.
Hammargren prescribed quaaludes, valium, elavil, triavil, meprobamate, chloral hydrate, phenobarbitol, seconal, and talwin to combat her anxiety.
Pentobarbital (a barbiturate), meprobamate (a tranquilizer sold as Equanil and Miltown) and phensuximide (an anticonvulsant) are still measurable in that groundwater plume.
Its metabolism in the liver generates an anxiety-reducing agent that was previously marketed as a controlled substance (meprobamate).