meperidine


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analgesic

 [an″al-je´zik]
1. relieving pain.
2. pertaining to analgesia.
3. an agent that relieves pain without causing loss of consciousness.
narcotic analgesic opioid analgesic.
nonsteroidal antiinflammatory analgesic (NSAIA) nonsteroidal antiinflammatory drug.
opiate analgesic (opioid analgesic) any of a class of compounds that bind with a number of closely related specific receptors (opioid receptors) in the central nervous system to block the perception of pain or affect the emotional response to pain; such compounds include opium and its derivatives, as well as a number of synthetic compounds, and are used for moderate to severe pain. Chronic administration or abuse may lead to dependence.

meperidine

(mə-pĕr′ĭ-dēn′)
n.
A synthetic opioid, C15H21NO2, used in its hydrochloride form as an analgesic and sedative. Also called pethidine.

meperidine

An IV opioid analgesic with an active metabolite, normeperidine.
 
Route
Parenteral, oral.
 
Pharmacologic effects
Potent blocker of pain messages to the brain.

Contraindications
Co-administration with MAOI antidepressants (may cause dizziness, lightheadedness, nausea); ritonavir.

T1/2
2–5 hours for relief of moderate to severe pain.
 
Therapeutic range
200–800 ng/mL, meperidine; 130–480 ng/mL, normeperidine.
 
Toxic range
> 7 mg/L.
 
Specimen
Random urine, serum.
 
Method
Urine, TLC; serum, GC.

meperidine

Demerol Pain management An IV agonist opioid analgesic, with an active metabolite, normeperidine Route Parenteral, oral Pharmacologic effects Powerful blocker of pain messages to the brain Contraindications Not coadministered with MAOI antidepressants–may cause dizziness, lightheadedness, nausea. See Opioids.

meperidine

See PETHIDINE.
References in periodicals archive ?
Meperidine decreases the shivering threshold twice as much as the vasoconstriction threshold.
A comparison of the haemodynamic effects of intrathecal meperidine, meperidine-bupivacaine mixture, and hyperbaric bupivacaine.
With respect to the possible culprit, meperidine, there was a close relationship between meperidine injection and seizure as the patient began seizing almost immediately after the IV injection of meperidine.
Previous data has also demonstrated an increased requirement for meperidine and morphine in smokers20.
TABLE 1: Reaction time of animals in hot plate test: 0,15, 30, 60, and 90 min after treatment of anethole (62.5,125, 250, and 500 mg/kg, p.o.) and meperidine (50 mg/kg, i.p.).
(1989) in their randomized study reported that naloxone was used far less in infants whose mothers received fentanyl for pain relief than infants whose mothers received meperidine for the same indication (2% vs.
Conclusion: Morphine in comparison to meperidine or methadone is more beneficial in reducing pain or analgesic need when is added to bupivacain injection following arthroscopic menisectomy.
The record from one hospitalization reported that she had made angry, profanity-laced requests for meperidine and promethazine.
It comprises of Meperidine 25 mg/ml, Promethazine 6.5 mg/ml, and chlorpromazine 6.5 mg/ml which was used in a dose of 0.1 ml/kg.7 In 1958 Smith8 used this mixture intramuscularly in 670 patients.
Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anaesthesia.