Histologic analysis showed a mild to moderate, multifocal, perivascularly accentuated, lymphohistiocytic meningoencephalomyelitis
, which affected the cerebrum, cerebellum (Figure 1, panel A), brain stem, medulla oblongata, and cervical spinal cord.
A comparative pathological study on canine necrotizing meningoencephalitis and granulomatous meningoencephalomyelitis
. J Vet Med Sci, v.65, n.11, p.1233-1239, 2003.
Pathologic examination revealed nonsuppurative meningoencephalomyelitis
with formation of eosinophilic intracytoplasmic inclusion bodies in all 3 animals; reverse transcription PCR and immunohistochemical staining excluded the possibility of infection with the canine distemper virus.
Importantly, 4 patients did not have a zoster rash at the time, underscoring the critical role of CSF PCR testing in cases that may be clinically confusing. In another study, CSF PCR results from 514 consecutive HIV-infected patients with neurologic disease were positive for VZV DNA in 13 (2.5%) of the patients. Four of the 13 patients had VZV encephalitis or meningoencephalomyelitis
and received appropriate antiviral therapy; in 2 patients, viral DNA could no longer be detected in the CSF after therapy, and the patients' clinical conditions improved.
was largely confined to gray matter in the brain and spinal cord, with most severe lesions in the cerebellar folia and brainstem and throughout all segments of the spinal cord gray matter.
Detection of EV71 as the single most prevalent EV type associated with NP-AFP is of clinical significance because it is regarded as the most virulent neurotropic EV, next to poliovirus, associated with poliomyelitis-like paralytic disease, meningitis, meningoencephalomyelitis
, Guillain-Barre syndrome, transeverse myelitis, cerebellar ataxia, opsoclonus-myoclonus syndrome, benign intracranial hypertension, brainstem encephalitis (34-36), and frequent epidemics of hand, foot, and mouth disease with substantial illness and death worldwide affecting >500,000 children in the Asia-Pacific region and causing >200 deaths in China during the past decade (37-39).
Clinical manifestations range from inapparent infection to severe meningoencephalomyelitis
Outbreak of orthoreovirus-induced meningoencephalomyelitis
In 5%-30% of clinical cases, a second neurologic phase may occur with aseptic meningitis (50% of the cases), meningoencephalitis (40%), or meningoencephalomyelitis
The clinical syndrome was classified, in accordance with Kaiser et al., into febrile form (4 cases), aseptic meningitis (3 cases), encephalitis (2 cases), meningoencephalitis (8 cases), and meningoencephalomyelitis
(3 cases) (7).
Other human pathogens in the genus Flavivirus that will be discussed in this review include yellow fever virus (YFV), dengue virus (DENV), Israel turkey meningoencephalomyelitis
virus, and Bagaza virus.
by Angiostrongylus (= Parastrongylus) cantonensis in an American miniature horse.