membranous nephropathy


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Related to membranous nephropathy: membranoproliferative glomerulonephritis, focal segmental glomerulosclerosis

nephropathy

 [nĕ-frop´ah-the]
1. any disease of the kidneys. adj., adj nephropath´ic.
2. any disease of the kidneys; see also nephritis. Called also nephrosis. adj., adj nephropath´ic.
AIDS nephropathy former name for HIV-associated nephropathy.
analgesic nephropathy interstitial nephritis with renal papillary necrosis, seen in patients with a history of abuse of analgesics such as aspirin or acetaminophen alone or in combination.
diabetic nephropathy the nephropathy that commonly accompanies later stages of diabetes mellitus; it begins with hyperfiltration, renal hypertrophy, microalbuminuria, and hypertension; in time proteinuria develops, with other signs of decreasing function leading to end-stage renal disease.
gouty nephropathy any of a group of chronic kidney diseases associated with the abnormal production and excretion of uric acid.
heavy metal nephropathy the kidney damage resulting from any of various forms of heavy metal poisoning, usually in the form of tubulointerstitial nephritis. The most common metals involved are cadmium, lead, and mercury.
HIV-associated nephropathy renal pathology in patients infected with the human immunodeficiency virus, similar to focal segmental glomerulosclerosis, with proteinuria, enlarged kidneys, and dilated tubules containing proteinaceous casts; it may progress to end-stage renal disease within weeks.
hypokalemic nephropathy nephropathy with hypokalemia, interstitial nephritis, swelling and vacuolization of proximal renal tubules, and progressive renal failure, resulting from conditions such as oncotic overloading of the kidney filtration mechanisms by sugars. See also potassium-losing nephropathy.
IgA nephropathy a chronic form marked by hematuria and proteinuria and by deposits of IgA immunoglobulin in the mesangial areas of the renal glomeruli, with subsequent reactive hyperplasia of mesangial cells. Called also Berger's disease and IgA glomerulonephritis.
ischemic nephropathy nephropathy resulting from partial or complete obstruction of a renal artery with ischemia, accompanied by a significant reduction in the glomerular filtration rate.
lead nephropathy the kidney damage that accompanies lead poisoning; lead deposits appear in the epithelium of the proximal tubules and as nuclear inclusions in cells. In time this leads to tubulointerstitial nephritis with chronic renal failure and other symptoms.
membranous nephropathy membranous glomerulonephritis.
minimal change nephropathy minimal change disease.
obstructive nephropathy nephropathy caused by obstruction of the urinary tract (usually the ureter), with hydronephrosis, slowing of the glomerular filtration rate, and tubular abnormalities.
potassium-losing nephropathy hypokalemic nephropathy after persistent potassium loss; it may be seen in metabolic alkalosis, adrenocortical hormone excess, or in intrinsic renal disease such as renal tubular acidosis or hyperplasia of juxtaglomerular cells. Called also potassium-losing nephritis.
reflux nephropathy childhood pyelonephritis in which the renal scarring results from vesicoureteric reflux, with radiological appearance of intrarenal reflux.
salt-losing nephropathy intrinsic renal disease causing abnormal urinary sodium loss in persons ingesting normal amounts of sodium chloride, with vomiting, dehydration, and vascular collapse. Called also salt-losing nephritis.
urate nephropathy (uric acid nephropathy) any of a group of kidney diseases occurring in patients with hyperuricemia, including an acute form, a chronic form (gouty nephropathy), and nephrolithiasis with formation of uric acid calculi.

membranous nephropathy

membranous nephropathy

A glomerular disease of unknown cause that produces nephrotic syndrome. It may be distinguished from lipoid nephrosis by immunofluorescence and electron microscopy. See: glomerular disease; nephrotic syndrome

Treatment

Treatment consists of corticosteroids with or without other immunosuppressive drugs.

See also: nephropathy
References in periodicals archive ?
Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.
A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy.
Membranous nephropathy has been associated with tuberculosis and thus could explain the patient's nephrotic syndrome.
Plateletendothelial cell adhesion molecule-1 and angiogenic factor expression in idiopathic membranous nephropathy.
51) Furthermore, GBM splitting with variable thickness and an irregular outer contour is not specific for Alport syndrome, as similar changes may be seen with hyperfiltration injury,52 chronic lesions of membranous nephropathy, postinfectious glomerulonephritis where the immune complex deposits have been extensively resorbed, (53) and as noted above, IgA nephropathy.
My colleagues and I have reported 2 cases of de novo membranous nephropathy in renal allografts with unusual histology.
Acthar Gel (repository corticotropin) in 20 patients with nephrotic syndrome due to idiopathic membranous nephropathy (iMN) have been published in the journal Nephrology Dialysis Transplantation.
Questcor has company-sponsored clinical studies underway to investigate the safety and efficacy of Acthar in the treatment of amyotrophic lateral sclerosis (ALS), diabetic nephropathy, idiopathic membranous nephropathy and lupus.
In addition to this ALS trial, Questcor has on-going trials in idiopathic membranous nephropathy, systemic lupus erthymatosus, and diabetic nephropathy," continued Dr.
The company's projects underway are for the treatment of lupus, idiopathic membranous nephropathy, diabetic nephropathy and amyotrophic lateral sclerosis (ALS).
Some common idiopathic type kidney disorders that can result in nephrotic syndrome include, among others, idiopathic membranous nephropathy, focal segmental glomerulosclerosis, IgA nephropathy and minimal change disease.

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