ObsEva is developing OBE022, a potential first-in-class, once daily, oral and selective prostaglandin F2alpha receptor antagonist, which is designed to control preterm labor by reducing inflammation, decreasing uterine contractions, preventing cervical changes and fetal membrane rupture
without causing the potentially serious side effects to the fetus seen with non-specific prostaglandin synthesis inhibitors (NSAIDs).
The pressure necessary to cause membrane rupture
experimentally not only is greater than the base line resting tone of the intrauterine cavity, but also generally exceeds that generated by normal labour.
During the procedure, membrane rupture
was observed in two patients (9.1%) in the emergency group, and no membrane rupture
associated with the procedure was seen in any of the therapeutic cerclage group.
A post-mortem examination gave the cause of death as hyaline membrane disease and lung damage, caused by the membrane rupture
, with premature birth a factor.
FDA listed several limitations that it said are typically stated in ROM device labeling, including that "A negative result does not assure the absence of membrane rupture
The aim of our study was to analyze the clinical characteristics, management, therapeutic options, and consequent results of PLF using a case of RW membrane rupture
that occurred after sneezing and systematically reviewing the literature pertaining to this topic.
They also collected samples from a second, smaller group of 87 women who presented to the hospital with premature membrane rupture
. All patients were seen at Queen Charlotte's and Chelsea Hospital and Chelsea and Westminster Hospital.
Sparks will use the money to fund pioneering research into treatment for fetal membrane rupture
, which causes 40 percent of premature births.
during cerclage was not noted, and the cerclage procedure was completed in all 23 cases.
A vaginal swab and a cervical swab were collected within 12 h of membrane rupture
of PPROM cases, and the control group were collected at 28-36+6 weeks of gestation during routine examination.
Oligohidroamniosis developed in the intrauterine thirty third week and early membrane rupture
occurred and the patient was hospitalized in newborn intensive care unit after intubating due to superficial respiration.
For the other 18 pregnant women, with rupture of membranes before delivery, the median duration of membrane rupture
was 72h (1h to 42 days).