It is a small, integral membrane enzyme
that coordinates a particularly complex reaction: its lipid substrate is hydrophobic (repelled by water) and resides in cell membranes, while its co-substrate, ATP, is entirely water soluble.
KEY WORDS: AY2-microglobulin Ligustrazine Neonatal scleredema Renal brush border membrane enzyme Renal injury.
The enzymes that bound to the brush border of microvillous membrane including alkaline phosphatase (ALP) leucineaminopeptidase (LAP) -glutamyltransferase (-GT) are collectively called renal brush boarder membrane enzyme (RBBME).
Objective: To evaluate renal brush border membrane enzymes in urine as an indicator for renal injury in neonatal scleredema(NS).
Urine samples were collected to detect renal brush border membrane enzymes (RBBME) by ELISA and AY2-microglobulin (AY -MG) by radioimmunoassay (RIA).
These structural and functional abnormalities of insulin molecule may contribute to the pathogenesis of insulin resistance.12 A study involving type-I diabetes mellitus patients looked for the toxic effects of reactive aldehydes MG and glyoxal in young, complication-free type-I patients by assessing activity of the ubiquitous membrane enzyme
, Na+/K+ ATPase.
The membrane enzymes there are alanine aminopeptidase (AAP) (EC 188.8.131.52) and [gamma]-glutamyltransferase (GGT) (EC 184.108.40.206).
The Activity of Membrane Enzymes. AAP and GGT activities were measured.
In this study, membrane enzymes including AAP and GGT or lysosomal enzymes NAG and [beta]-GD were measured.
This results in alterations of cellular permeability and activity of various membrane enzymes
. Ketoconazole also has anti-inflammatory properties through an action on leucotriene synthesis and it has an action onkeratinisation process through an action on all trans retinoic acid (Levine, 1982).
Often they are membrane enzymes
, with all the attendant difficulties of purification and characterization.
He used the transport of glucose and amino acids, and renal brush border membrane enzymes
as sensitive biochemical markers of renal damage to assess the protective effect of immunization with pili.