BACE1

(redirected from memapsin-2)

BACE1

B-site amyloid precursor protein (APP) cleaving enzyme. An aspartic-acid protease encoded by BACE1 on chromosome 11q23.2.-q23.3, which is linked to the pathogenesis of Alzheimer's disease and the formation of myelin sheaths in peripheral nerve cells. BACE1 is a transmembrane aspartic protease (beta-secretase) found in the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. It cleaves amyloid precursor protein (APP) in the brain into amyloid beta peptide, a major component of the amyloid plaques of Alzheimer's disease (AD), the deposition of which is the central pathology in AD, for which BACE1 is potential therapeutic target.
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The initial step in amyloid formation is the cleavage of APP by [beta]-APP cleavage enzyme (BACE-1; also known as memapsin-2 or Asp-2), which produces a large soluble APP fragment and a small membrane-bound fragment (2-5).
Subsite specificity of memapsin-2 (R-secretase): implications for inhibitor design.