melphalan


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melphalan

 [mel´fah-lan]
a cytotoxic alkylating agent derived from nitrogen mustard, used as an antineoplastic agent, primarily for treatment of multiple myeloma; administered orally or intravenously.

melphalan

/mel·pha·lan/ (mel´fah-lan) a cytotoxic alkylating agent derived from mechlorethamine, used as an antineoplastic.

melphalan

[mel′fəlan]
an antineoplastic alkylating agent.
indications It is prescribed in the treatment of malignant neoplastic diseases, including palliative treatment of multiple myeloma and nonresectable ovarian carcinoma.
contraindications Pregnancy, recent exposure to antineoplastic medication or to radiation, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse effects are bone marrow depression, nausea, and vomiting.

melphalan

An alkylating nitrogen mustard used to treat ovarian cancer, myeloma, and occasionally melanoma.

Adverse effects
Nausea, vomiting, oral ulcers, myelosuppression, mutagenesis, allergic reactions.

melphalan

Alkeran® Oncology An oral alkylating anticancer nitrogen mustard agent used to treat  ovarian CA and myeloproliferative disease Adverse effects Myelosuppression, mutagenesis

melphalan

A drug used in the treatment of POLYCYTHAEMIA VERA, chronic LEUKAEMIA and MYELOMATOSIS. A brand name is Alkeran.

melphalan

(mel´fəlan´),
n brand name: Alkeran;
drug class: antineoplastic;
action: responsible for cross-linking DNA strands, which leads to cell death;
uses: palliative treatment of multiple myeloma and nonresectable epithelial carcinoma of the ovary.

melphalan

a cytotoxic nitrogen mustard alkylating agent used as an antineoplastic.
References in periodicals archive ?
This study suggests that patients who have complete hematologic remission with melphalan and ASCT could be eligible for renal transplant with good outcomes.
Treatment with oral melphalan plus dexamethasone produces long-term remissions in AL amyloidosis.
Although high-dose therapy with melphalan increases complete remission rates and overall survival, most patients will still relapse over time and die from MM.
At 2 years, patients taking the higher dose of melphalan experienced a higher rate of gastrointestinal toxicity and more mucositis than did those taking the lower dose, although duration of grade 3-4 neutropenia was similar.
Complete remission of advanced cutaneous leiomyosarcoma following isolated limb perfusion with high-dose tumour necrosis factor-alpha and melphalan.
Dr Roberts, founder of the Dispensing Doctors Association, is accused of irresponsibly prescribing Melphalan tablets to Mrs Doswell, of Lammas Close, Husbands Bosworth, Leicestershire, at his practice in the same village, on July 4 1997.
Similarly, high doses of melphalan (more than 350 milligrams) appeared to spike the incidence of leukemia to 100 times the rate in women receiving no adjuvant therapy.
Analysis of agonists in combination with dexamethasone or melphalan in 83 cell lines revealed substantial activity in MM and diffuse large B cell lymphoma cell lines.
Janssen-Cilag International NV announced today that treatment with VELCADE(bortezomib), in combination with melphalan and prednisone (VMP), delivered a significant long-term overall survival (OS) benefit of 13.
This Phase II study compared the safety, tolerability and pharmacokinetic profiles of a new PG-free melphalan intravenous formulation and the current clinically used intravenous formulation of melphalan (sold as Alkeran[R]) for multiple myeloma patients undergoing autologous transplantation.
5% for patients treated with bortezomib plus melphalan and prednisone (Vc+M+P), compared to 54% (p=0.