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Related to meloxicam: cyclobenzaprine


a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis; administered orally.


Apo-Meloxicam (CA), Co Meloxicam (CA), Dom-Meloxicam (CA), Gen-Meloxicam (CA), Mobic, Mobicox (CA), Novo-Meloxicam (CA), PHL-Meloxicam (CA), Ratio-Meloxicam (CA)

Pharmacologic class: Nonopioid analgesic, nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Analgesic, anti-inflammatory drug

Pregnancy risk category C

FDA Box Warning

• Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke. Risk may increase with duration of use. Patients with cardiovascular disease or risk factors for it may be at greater risk.

• Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation. These events can occur at any time during use and without warning. Elderly patients are at greater risk.

• Drug is contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery.


Unknown. Thought to reduce inflammation and pain by inhibiting prostaglandin synthesis of the enzyme cyclooxygenase.


Oral suspension: 7.5 mg/5 ml

Tablets: 7.5 mg, 15 mg

Indications and dosages

Osteoarthritis; rheumatoid arthritis

Adults: 7.5 mg P.O. once daily; may increase to 15 mg/day

Juvenile arthritis

Children ages 2 and older: 0.125 mg/kg P.O. once daily, up to a maximum of 7.5 mg


• Hypersensitivity to drug, its components, or other NSAIDs


Use cautiously in:

• bleeding disorders, GI or cardiac disorders, severe renal impairment, severe hepatic disease, asthma, peptic ulcer disease

• concurrent aspirin, oral anticoagulant, or corticosteroid therapy

• elderly or debilitated patients

• pregnant or breastfeeding patients.


• Before starting therapy, ask patient about aspirin sensitivity and allergies to other NSAIDs. If patient is dehydrated, provide adequate fluids.

Adverse reactions

CNS: headache, dizziness, syncope, malaise, fatigue, asthenia, depression, confusion, nervousness, drowsiness, insomnia, vertigo, tremor, paresthesia, anxiety, seizures

CV: hypertension, hypotension, palpitations, angina, vasculitis, heart failure, arrhythmias, MI

EENT: abnormal vision, conjunctivitis, hearing loss, tinnitus, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, colitis, GI ulcers with perforation, abdominal pain, dyspepsia, gastroesophageal reflux, esophagitis, flatulence, ulcerative stomatitis, dry mouth, pancreatitis, GI hemorrhage

GU: urinary frequency, urinary tract infection, albuminuria, hematuria, renal failure

Hematologic: anemia, purpura, leukopenia, thrombocytopenia

Hepatic: hepatitis

Musculoskeletal: joint pain, back pain

Metabolic: dehydration

Respiratory: upper respiratory infection, dyspnea, coughing, asthma, bronchospasm

Skin: rash, urticaria, pruritus, bullous eruption, sweating, alopecia, photosensitivity, angioedema

Other: altered taste, increased appetite, weight gain or loss, hot flashes, fluid retention and edema, masking of infection symptoms, hypersensitivity reactions including anaphylaxis


Drug-drug. Angiotensin-converting enzyme inhibitors: decreased antihypertensive effect

Anticoagulants: increased risk of bleeding

Aspirin: increased meloxicam blood level, increased risk of toxicity

Cholestyramine: decreased meloxicam blood level

Furosemide, thiazides: decreased diuretic effect

Lithium: increased lithium blood level

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, gamma-glutamyl transferase: increased levels

Hemoglobin, platelets, white blood cells: decreased values

Drug-behaviors. Alcohol use, smoking: increased risk of GI irritation and bleeding

Patient monitoring

Closely monitor patient with aspirin-sensitivity asthma, because of risk of severe bronchospasm.

• In prolonged therapy, monitor CBC and kidney and liver function tests.

Assess for cardiovascular disorders and hepatotoxicity.

• Monitor patient for fluid retention and weight gain.

Patient teaching

Instruct patient to immediately report signs and symptoms of hepatotoxicity, including right upper quadrant pain, nausea, fatigue, lethargy, pruritus, and jaundice.

• Tell patient to report abdominal pain, blood in stool or emesis, or black tarry stools.

• Instruct patient to avoid alcohol and smoking.

• Caution pregnant patient to avoid drug, especially during third trimester.

• Tell patient to consult prescriber before taking over-the-counter preparations.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.


/mel·ox·i·cam/ (mĕ-lok´sĭ-kam) a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis.


A nonsteroidal anti-inflammatory drug used to treat arthritis.


a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis. It is administered orally.


An oral NSAID used for osteoarthritis.


a nonsteroidal anti-inflammatory drug used in dogs for management of pain.
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References in periodicals archive ?
Conclusions and clinical relevance: Results indicated that meloxicam administered at a dose of 1 mg/kg PO in chickens appears to maintain plasma concentrations equivalent to those reported to be therapeutic for humans for 12 hours.
Therefore, the aim of this study was to assess the possible systemic and neurotoxic effects of epidural administration of meloxicam to rabbits at a dose of 0.
Target: IV/IM meloxicam pain drug, contract manufacturing facility, royalty and formulation business
Ten calves with a history of swelling in the umbilical region were treated with Strepto-Penicillin and Meloxicam administered intramuscularly for 5 days and routine dressing of the wound was carried out (Ganga et al.
They then gave half the owners a placebo and half the meloxicam for three weeks without either knowing it.
11) At the doses shown in figure 3, naproxen and ibuprofen have highest levels of COX-1 inhibition, diclofenac and meloxicam have moderate levels, and rofecoxib has the lowest levels of COX-1 inhibition.
Ainda hoje sao de escolha os fracos inibidores de COX-1, mas alguns destes AINES que inibem preferencialmente a enzima COX-2, tais como meloxicam, etodolaco e nimesulida, os quais sao considerados inibidores parcialmente seletivos da COX-2, apresentam favoravel tolerabilidade gastrintestinal e renal preservando o organismo de reacoes adversas ligadas a excessiva inibicao da COX-1 (NOBLE et al.
como el meloxicam (MELOX), es beneficioso en episodios isquemicos, con menos efectos secundarios que otros antiinflamatorios no esteroides (AINE), y la asociacion con otros medicamentos le confiere mayor proteccion (25.
The research team gave baboons and humans a non-steroidal anti-inflammatory drug (NSAID) called meloxicam and they saw a subsequent increase in the numbers of hematopoietic stem cells in the blood stream.