Also found in: Dictionary, Acronyms, Wikipedia.
Related to meloxicam: cyclobenzaprine


a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Apo-Meloxicam (CA), Co Meloxicam (CA), Dom-Meloxicam (CA), Gen-Meloxicam (CA), Mobic, Mobicox (CA), Novo-Meloxicam (CA), PHL-Meloxicam (CA), Ratio-Meloxicam (CA)

Pharmacologic class: Nonopioid analgesic, nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Analgesic, anti-inflammatory drug

Pregnancy risk category C

FDA Box Warning

• Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke. Risk may increase with duration of use. Patients with cardiovascular disease or risk factors for it may be at greater risk.

• Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation. These events can occur at any time during use and without warning. Elderly patients are at greater risk.

• Drug is contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery.


Unknown. Thought to reduce inflammation and pain by inhibiting prostaglandin synthesis of the enzyme cyclooxygenase.


Oral suspension: 7.5 mg/5 ml

Tablets: 7.5 mg, 15 mg

Indications and dosages

Osteoarthritis; rheumatoid arthritis

Adults: 7.5 mg P.O. once daily; may increase to 15 mg/day

Juvenile arthritis

Children ages 2 and older: 0.125 mg/kg P.O. once daily, up to a maximum of 7.5 mg


• Hypersensitivity to drug, its components, or other NSAIDs


Use cautiously in:

• bleeding disorders, GI or cardiac disorders, severe renal impairment, severe hepatic disease, asthma, peptic ulcer disease

• concurrent aspirin, oral anticoagulant, or corticosteroid therapy

• elderly or debilitated patients

• pregnant or breastfeeding patients.


• Before starting therapy, ask patient about aspirin sensitivity and allergies to other NSAIDs. If patient is dehydrated, provide adequate fluids.

Adverse reactions

CNS: headache, dizziness, syncope, malaise, fatigue, asthenia, depression, confusion, nervousness, drowsiness, insomnia, vertigo, tremor, paresthesia, anxiety, seizures

CV: hypertension, hypotension, palpitations, angina, vasculitis, heart failure, arrhythmias, MI

EENT: abnormal vision, conjunctivitis, hearing loss, tinnitus, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, colitis, GI ulcers with perforation, abdominal pain, dyspepsia, gastroesophageal reflux, esophagitis, flatulence, ulcerative stomatitis, dry mouth, pancreatitis, GI hemorrhage

GU: urinary frequency, urinary tract infection, albuminuria, hematuria, renal failure

Hematologic: anemia, purpura, leukopenia, thrombocytopenia

Hepatic: hepatitis

Musculoskeletal: joint pain, back pain

Metabolic: dehydration

Respiratory: upper respiratory infection, dyspnea, coughing, asthma, bronchospasm

Skin: rash, urticaria, pruritus, bullous eruption, sweating, alopecia, photosensitivity, angioedema

Other: altered taste, increased appetite, weight gain or loss, hot flashes, fluid retention and edema, masking of infection symptoms, hypersensitivity reactions including anaphylaxis


Drug-drug. Angiotensin-converting enzyme inhibitors: decreased antihypertensive effect

Anticoagulants: increased risk of bleeding

Aspirin: increased meloxicam blood level, increased risk of toxicity

Cholestyramine: decreased meloxicam blood level

Furosemide, thiazides: decreased diuretic effect

Lithium: increased lithium blood level

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, gamma-glutamyl transferase: increased levels

Hemoglobin, platelets, white blood cells: decreased values

Drug-behaviors. Alcohol use, smoking: increased risk of GI irritation and bleeding

Patient monitoring

Closely monitor patient with aspirin-sensitivity asthma, because of risk of severe bronchospasm.

• In prolonged therapy, monitor CBC and kidney and liver function tests.

Assess for cardiovascular disorders and hepatotoxicity.

• Monitor patient for fluid retention and weight gain.

Patient teaching

Instruct patient to immediately report signs and symptoms of hepatotoxicity, including right upper quadrant pain, nausea, fatigue, lethargy, pruritus, and jaundice.

• Tell patient to report abdominal pain, blood in stool or emesis, or black tarry stools.

• Instruct patient to avoid alcohol and smoking.

• Caution pregnant patient to avoid drug, especially during third trimester.

• Tell patient to consult prescriber before taking over-the-counter preparations.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A nonsteroidal anti-inflammatory drug used to treat arthritis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


An oral NSAID used for osteoarthritis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
Meloxicam is a NSAID that preferentially inhibits the cyclooxygenase-2 enzymatic pathway, and multiple studies have evaluated pharmacokinetics in avian species.
Results of solubility studies showed a satisfactory increase in the solubility of meloxicam, when it was complexed with carriers, [beta]-Cyclodextrin and maltodextrin.
We postulate that the topically applied combination meloxicam and lidocaine would synergistically reduce nociceptive thresholds in patients diagnosed with vulvodynia, resulting in symptom amelioration.
There are few reports in the literature regarding clinical and neurological changes in response to the epidural administration of meloxicam, and no study has assessed possible formation of histopathological lesions or neurotoxicity associated with a therapeutic dose.
The animal received perioperative butorphanol (2 mg/kg BW intramuscularly), meloxicam (0.5 mg/kg BW intramuscularly), clindamycin (20 mg/kg BW intravenously), enrofloxacin (15 mg/kg BW subcutaneously diluted 1: 10 in lactated ringer's solution), and intraoperative lactated ringer's solution (10 ml/kg/hr BW intravenously).
The dogs were treated with cleaning of ear canals with 2% Boric acid and 2% Acetic acid solution, Meloxicam (Melonex (a)) @ 0.2 mg/kg b.wt.
The medication, Vivlodex, is made using a proprietary technology for producing submicron-size particles of meloxicam that are 10 times smaller than their traditional size, decreasing dissolution time.
IV/IM meloxicam is a proprietary, Phase III-ready, long-acting COX-2 NSAID for moderate to severe acute pain.
A study at North Carolina State College of Veterinary Medicine, published in the Journal of Veterinary Internal Medicine, put science to work to investigate the caregiver placebo effect in a clinical trial of meloxicam, a nonsteroidal anti-inflammatory drug commonly used to relieve pain in cats with degenerative joint disease.
(10) Diclofenac, celecoxib and meloxicam preferentially inhibit COX-2, while naproxen and ibuprofen preferential inhibit COX-1.
We used meloxicam, a nonsteroidal antiinflammatory drug (NSAID), as a positive control drug in our experiments because it is widely used as a pain reliever in clinical treatment of intervertebral disc degeneration disease [18,19].