melittin


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mel·it·tin

(mel'i-tin),
The principal component in bee venom; melittin is a peptide amide containing 26 amino acyl residues and is a hemolysin.
[G. melitta, bee, + -in]

melittin

A 26-residue polypeptide which bears the toxic and haemolytic components of bee venom. It inhibits Ca2+/calmodulin-dependent protein kinase II, myosin light-chain kinase, Na+/K+-ATPase (synaptosomal membrane) and protein kinase C; it lyses cell membranes.
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References in periodicals archive ?
Melittin in BV consists about 50% of the dry weight, it has many potential effects such as antiviral, anti-bacterial and anti-inflammatory action in a different type of cells (8,9).
The novel antimicrobial peptide Caeridin-a1, melittin, and bradykinin were tested in the membrane permeability studies.
In the present study, we aimed to disclose the crucial genes associated with BC and investigate the effect of melittin on the identified crucial genes in BC.
The analysis also indicated the presence of melittin (2.8kDa), equivalent to 53.5% melittin for type 1 apitoxin, and 50.2% melittin for type 2 apitoxin.
* Raghuraman H, Chattopadyay A (2007) Melittin: a membrane-active peptide with diverse function, Biosci Rep, 27: 189-223.
BV proteins, mainly melittin, are also widely used in the treatment of arthritis, frozen shoulder, diseases of the central and peripheral nervous system (CNS, PNS), skin diseases, heart and blood system related diseases, cancer, ulcer, colitis, and neuritis [14, 15, 17, 19, 24-28].
Bee venom is a complex toxin comprising various kinds of chemicals including melittin, apamin, adolapin, phospholipase A2, hyaluronidase, and histamine [3,4], and generalized allergic reaction to these chemicals develops in 0.3~5% of people [2].
Li et al., "Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1"/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model," Molecular Medicine Reports, vol.
Bae et al., "Melittin has a chondroprotective effect by inhibiting MMP-1 and MMP-8 expressions via blocking NF-[kappa]B and AP-1 signaling pathway in chondrocytes," International Immunopharmacology, vol.
The resulting constructs carried Nterminal melittin signal sequence for secretion.
Bait from ground spraying 631 500 olive trees in Laconia regional unit for 3 sprays in Kallithea local communities Polovitsas, Mola Oars, Metamorphosis, Agios Nikolaos melittin, svelte, Myrsini.