melanotic schwannoma

melanotic schwannoma

A rare form of schwannoma characterised by heavy deposition of melanin pigment (Fontana-Masson, S-100, HMB-45, all +ve) linked to melanosomes and premelanosomes. It is often (50% of cases) associated with Carney syndrome (myxomas in various sites, spotty pigmentation, endocrine hyperactivity).

Prognosis
Most melanotic schwannomas behave benignly; they may metastasise.
References in periodicals archive ?
The article by Alexiev et al highlights the importance of diagnostic recognition, ancillary molecular genetic testing, and close clinical follow-up of patients with melanotic schwannoma. Deeken-Draisey et al review current procedural terminology (CPT) coding for surgical pathology, highlighting that the appropriate extent of physician involvement in CPT coding is a matter of some debate, and a multidisciplinary approach involving both health care providers and professional coders appears to be the best way to achieve accuracy.
Psammomatous melanotic schwannoma, plexiform schwannoma, microcystic/reticular schwannoma are further variants of schwannoma8,9.
Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome.
Soon, "Solitary gastric melanotic schwannoma: sonographic findings," Journal of Clinical Ultrasound, vol.
Melanotic Schwannoma (MS) is a rare, distinctive, potentially malignant neoplasm that is categorized as a variant of Schwannoma [1,2].
Melanotic Schwannoma can be divided into psammomatous and nonpsammomatous types and about half of the cases with psammomatous MS are related to Carney complex [1].
Pathological types of tumors included schwannoma (31 cases) [Figure 5], epidermoid cyst (12 cases), neurofibroma (5 cases), hemangioma (2 cases), and melanotic schwannoma (1 case).
The differential diagnoses include pigmented (melanotic) neurofibroma, psammomatous melanotic schwannoma, and desmoplastic (neurotrophic) melanoma.
They acquire melanin and these lesions include Meningioma, Medulloblastoma, Astrocytoma, Melanotic Schwannoma, Pitutary tumours and Choroid plexus Papilloma.
Melanotic schwannoma (MS) is a nerve sheath tumor with a uniform composition of variably melaninproducing Schwann cells and metastatic potential.
Psammomatous melanotic schwannoma may present rarely as a colorectal polyp comprising epithelioid cells with psammoma bodies and melanin pigment.