melanosis coli


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melanosis

 [mel″ah-no´sis]
1. disordered melanin production, with darkening of the skin; called also melanism.
2. a disorder of pigment metabolism.
melanosis co´li brown-black discoloration of the mucosa of the colon.
melanosis i´ridis (melanosis of the iris) abnormal pigmentation of the iris by infiltration of melanoblasts.

mel·a·no·sis co·'li

melanosis of the large intestinal mucosa due to accumulation of pigment of uncertain composition within macrophages in the lamina propria.
A benign condition characterised by segmental or global darkening of the colonic mucosa coupled with chronic constipation, due to prolonged abuse of cascara/sagrada-type laxatives

melanosis coli

Brown bowel syndrome A benign condition characterized by segmental or global darkening of the colonic mucosa coupled with chronic constipation, due to prolonged abuse of cascara/sagrada-type laxatives Clinical Abdominal pain, pancreatitis, biliary atresia, cirrhosis, peptic ulcer disease, mucoviscidosis. See Laxative.

mel·a·no·sis co·li

(mel'ă-nō'sis kō'lī)
Melanosis of the large intestinal mucosa due to accumulation of pigment of uncertain composition within macrophages in the lamina propria.
References in periodicals archive ?
Additional diagnoses Factors potentially contributing to diagnostic difficulty Mucosal prolapse Only small focus affected Melanosis coli Nonpolypoid mucosa preferentially affected Polyps relatively or completely spared Eosinophilic colitis Confusion with reaction to adenoma Clinically occult Schistosomiasis Minute ova Affected nonpolypoid mucosa otherwise normal or focally normal Clinically occult Intestinal spirochetosis Minute bacteria Confined to nonpolypoid mucosa Affected nonpolypoid mucosa otherwise normal Clinically occult
These procedures revealed multiple white, sessile, nodular, polyplike lesions all less than 1 mm in size, scattered throughout the colon and rectum; in addition, the colon had an endoscopic appearance characteristic of melanosis coli (Figure 1).
Colonic biopsies showed marked melanosis coli (Figure 2) with multiple foci of lymphoid follicular hyperplasia corresponding to the white nodular patches distributed throughout the colon and rectum (Figure 3).