1011) PBD shows the presence of increased melanin in basal layer and
melanophages in the dermis.
In LP-like GVHD, focal increases in the granular cell layer and vacuolar changes of basal layer often reveal in the epidermis, and
melanophages and a large number of lymphocytic infiltrate are common showing in the dermis.
Histopathological examination revealed vacuolar degeneration on the basal layer,
melanophages, and lymphocytic infiltration in the upper dermis.
The biopsy revealed a mild superficial perivascular lymphohistiocytic infiltrate, scattered
melanophages in the papillary dermis and focal areas with smudging of the dermoepidermal junction.
There were also strikingly large, polyhedral or round, well-delimited pigment-containing
melanophages, which were more abundant than dendritic cells and were distributed throughout the neoplasm.
Histopathologic findings in the late pigmented lesion include a predominance of lympho cytes and
melanophages and a lichenoid tissue reaction.
These pigmented cells include
melanophages and cells that show squamous differentiation (figure, A).
Some of the benign nevi showed dermal fibroplasia without the associated changes in
melanophages, chronic inflammation, or vascular ectasia that characterize regression.
Significant hyperkeratosis, acanthosis, papillomatosis, focal and large globular amorphous material in the papillary dermis, scattered and periappendageal mononuclear cell infiltration in the dermis were seen in lichen amyloidosis (Figures 3) while basal layer pigmentation and dermal
melanophages was seen in macular amyloidosis (Figures 4).
In QS-Nd:YAG laser, melanin particles present within melanocytes, keratinocytes and dermal
melanophages are targeted.
The pathology may show a lentiginous pattern nevus, sometimes purely junctional, associated with increased melanin pigmentation, sometimes with pigment transfer into overlying stratum corneum ("pigmented parakeratosis") and
melanophages in the dermis.
abundant
melanophages suggesting pigment incontinence.
