1011) PBD shows the presence of increased melanin in basal layer and melanophages
in the dermis.
In LP-like GVHD, focal increases in the granular cell layer and vacuolar changes of basal layer often reveal in the epidermis, and melanophages
and a large number of lymphocytic infiltrate are common showing in the dermis.
Histopathological examination revealed vacuolar degeneration on the basal layer, melanophages
, and lymphocytic infiltration in the upper dermis.
The biopsy revealed a mild superficial perivascular lymphohistiocytic infiltrate, scattered melanophages
in the papillary dermis and focal areas with smudging of the dermoepidermal junction.
There were also strikingly large, polyhedral or round, well-delimited pigment-containing melanophages
, which were more abundant than dendritic cells and were distributed throughout the neoplasm.
Histopathologic findings in the late pigmented lesion include a predominance of lympho cytes and melanophages
and a lichenoid tissue reaction.
These pigmented cells include melanophages
and cells that show squamous differentiation (figure, A).
Some of the benign nevi showed dermal fibroplasia without the associated changes in melanophages
, chronic inflammation, or vascular ectasia that characterize regression.
Significant hyperkeratosis, acanthosis, papillomatosis, focal and large globular amorphous material in the papillary dermis, scattered and periappendageal mononuclear cell infiltration in the dermis were seen in lichen amyloidosis (Figures 3) while basal layer pigmentation and dermal melanophages
was seen in macular amyloidosis (Figures 4).
In QS-Nd:YAG laser, melanin particles present within melanocytes, keratinocytes and dermal melanophages
The pathology may show a lentiginous pattern nevus, sometimes purely junctional, associated with increased melanin pigmentation, sometimes with pigment transfer into overlying stratum corneum ("pigmented parakeratosis") and melanophages
in the dermis.
suggesting pigment incontinence.