melanoma in situ

melanoma in situ

A melanoma characterised by pagetoid spread of atypical cells or nests along the epidermal junction, extending up into the epidermis, but not the dermis. The cells are hyperchromatic, angulated and large. Mitoses may be seen.

DiffDx
Shave biopsied intradermal naevus.

mel·a·no·ma in si·tu

(mel'a-nō'mă in sī'tū)
A melanoma limited to the epidermis and composed of nests of atypical melanocytes and scattered single cells extending into the upper epidermis; local excision is curative although the lesion, if untreated, may soon invade the dermis. Malignant lentigo may be considered a slowly progressive type of melanoma in situ.
References in periodicals archive ?
Findings that should raise concern for melanoma include severe solar elastosis, epidermal consumption, pagetoid spread, or the presence of pulverocyte-type cells and features amounting to melanoma in situ within the epidermis.
He cited other investigators' study of 18 cases of subungual melanoma in situ, all marked by longitudinal melanonychia.
Melanoma in situ colonizing basal cell carcinoma: a case report and review of the literature.
Compared with those screened by a dermatologist, patients screened by a PA were significantly less likely to be diagnosed with melanoma in situ (1.1 versus 1.8 percent of visits; P = 0.02); for invasive melanoma (0.7 versus 0.8 percent of visits; P = 0.83) and nonmelanoma skin cancer (6.1 versus 6.1 percent of visits; P = 0.98), the differences were not significant.
This report documents a case involving a chiropractor who was diagnosed with melanoma in situ. This case is also presented from the patient's perspective to help illustrate the patient experience as well as the steps to proper management of this common but potentially deadly disorder.
Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ. Since clinical and dermoscopic examinations did not rule out a malignant skin lesion, surgical excision with primary closure under local anesthesia was performed.
Oral mucosal melanoma in situ is regarded as being already a T3 and should thus be treated as an invasive melanoma [1, 2, 9].
The samples were obtained from 69 patients with one of the following diagnosis: dysplastic nevus, melanoma in situ, and invasive melanoma (level III or IV according to Clark scale).
Pink in melanoma in situ tended to be present throughout the lesion (68% of pink lesions).
Recommended surgical margins based on depth are: 5 mm with a layer of subcutaneous fat for melanoma in situ, 1 cm down to the fascia for lesions with a Breslow depth [less than or equal to] 2 mm, and 2 cm down to the fascia for lesions with a depth >2 mm.
(4.) Tannous ZS, Lerner LH, Duncan LM, Mihm MC Jr, Flotte TJ: Progression to invasive melanoma from malignant melanoma in situ, lentigo maligna type.
In his practice, he uses imiquimod for patients with all types of BCC, for those with in situ and superficially invasive squamous cell carcinoma (SCC), and for those with melanoma in situ. "It's also good for premalignant epithelial targets such as actinic keratoses, actinic cheilitis, vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, and oral leukoplakia," he said.
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