CDK4(redirected from melanoma cutaneous malignant-3)
CDK4A gene on chromosome 12q14 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).
CDK4 mutations and those of related proteins (e.g., D-type cyclins, p16(INK4a) and Rb) occur in neoplasia.
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