Zinc is known for its antiapoptotic and antioxidant effects and for its role in melanogenesis
In the present study, the murine B16F10 melanoma cells were used because they possess melanogenic mechanism, are known to have intracellular tyrosinase, and can generate melanin, which are related to [alpha]-MSH stimulation and melanogenesis
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Irrespective of the type of organ involved, the diagnosis can be established by the presence of a marker of melanogenesis
, such as human melanoma black 45 (HMB-45) and positive smooth muscle cells (4).
Prior work has found conflicting evidence for the role of estrogens in melanogenesis
, said Ms.
Given oral glutathione's regulators' properties on melanogenesis
and pigment production in the skin, this safe, reduced dosing may also help decrease the melanin index in individuals with darker skin tones.
hierochuntica) is widely distributed in the Sahara-Arabian desert areas where whole specimens are used for treating fatigue and uterine hemorrhage in Egyptian folk healing (Nakashima, Matsuda, Oda, Nakamura, Xu, and Yoshikawa, "Melanogenesis
Interestingly, decreases in the number of melanocytes and melanogenesis
in the adipose tissue have been reported in vitiligo patients, and it has been suggested that metabolic disorders may develop in these patients (8).
While melanin formation (melanogenesis
) at the cellular level is a highly complicated process characterized by numerous chemical reactions, it can be broken down to three major stages: