MC4R

(redirected from melanocortin receptor 4)

MC4R

A gene on chromosome 18q22 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase and expressed in the brain, placenta and gut.

Molecular pathology
Defects in MC4R are linked to obesity.
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References in periodicals archive ?
Global Markets Direct's, 'Melanocortin Receptor 4 (MC4-R or MC4R) - Pipeline Review, H1 2016', provides in depth analysis on Melanocortin Receptor 4 (MC4-R or MC4R) targeted pipeline therapeutics.
The report provides comprehensive information on the Melanocortin Receptor 4 (MC4-R or MC4R), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
* The report provides a snapshot of the global therapeutic landscape for Melanocortin Receptor 4 (MC4-R or MC4R)
Two of the affected genes were estrogen receptor beta and the melanocortin receptor 4. Both are required for oxytocin release, thus changes in oxytocin/vasopressin signalling pathways may underpin the behavioural changes.
[6] Nonstandard abbreviations: POMC, proopiomelanocortin; MSH, melanocyte-stimulating hormone; ACTH, adrenocorticotropic hormone; MC4R, melanocortin receptor 4; 3'-UTR, 3' untranslated region; and BMI, body mass index.