MC1R

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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.

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References in periodicals archive ?

The melanocortin 1 receptor (MC1R) inhibits the inflammatory response in Raw 264.

Differential Expression of the KIT Gene in Liaoning Cashmere Goats with different Coat Colors

Two missense mutations in melanocortin 1 receptor (MC1R) are strongly associated with dark ventral coat color in reindeer (Rangifer tarandus).

Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene

On the surface of melanocytes is a protein known as melanocortin 1 receptor, or MC1R.

5 Surprising Facts About Redheads That Make Them Rare

Stage 1: Binding of melanocyte-stimulating hormone (a-MSH) to the receptor melanocortin 1 receptor (MC1R).

Fade unsightly skin pigmentation

The 32-year-old, from Castlemilk in Glasgow, has a mutation on the melanocortin 1 receptor (MC1R), a gene located on chromosome 16 of the human genome.

Riddy for anything; THE BIG INTERVIEWRiver City favourite Gary Lamont is so proud to be ginger, he's paying tribute to famous redheads in his one-man Edinburgh Fringe show

Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.

The effect of hair colour on anaesthetic requirements and recovery time after surgery

One theory is that redheads have a mutant melanocortin 1 receptor (MC1R) that interacts with endorphins that act as painkillers.

Redheads feel more pain: anecdotal evidence suggesting that redheads require more anesthetic than patients with other hair colours has been confirmed by a number of studies

Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation.

Role of estrogen, progesterone and prolactin in the etiopathogenesis of melasma in females

We're talking about people with a variant of a gene called the melanocortin 1 receptor that leads to red hair.

Defending Britain's red heads with a Gingerfest

We used the MeltCalc software that incorporates the thermodynamic effect of bulges on Tm predictions to design 1 probe with a 40-nt omission in the bovine MC1R melanocortin 1 receptor gene (MC1R), which we then tested experimentally.

Design and application of noncontinuously binding probes used for haplotyping and genotyping

The gene that has been studied most widely in this context is the melanocortin 1 receptor gene (MC1R) which is considered a low-penetrance melanoma-predisposing gene.

Does the sun play a role in the aetiology of malignant melanoma? A review

The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.