MC1R

(redirected from melanocortin 1 receptor)
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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
The extension locus encodes the melanocortin 1 receptor (MC1R) gene that has a seven transmembrane domains protein belonging to the G protein coupled receptors [6].
Rodgers is the editor of an art magazine called MC1R, for Melanocortin 1 Receptor, which is the name of the gene mutation associated with red hair.
A melanocortin 1 receptor (MC1R) gene polymorphism is useful for authentication of Massese sheep dairy products.
On the surface of melanocytes is a protein known as melanocortin 1 receptor, or MC1R.
* Stage 1: Binding of melanocyte-stimulating hormone (a-MSH) to the receptor melanocortin 1 receptor (MC1R).
Oh, "Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression," The Journal of Biological Chemistry, vol.
The 32-year-old, from Castlemilk in Glasgow, has a mutation on the melanocortin 1 receptor (MC1R), a gene located on chromosome 16 of the human genome.
[alpha]MSH recognizing melanocortin 1 receptor (MC1R) located on the cell membrane of melanocytes starts a series of signal pathways [1].
Fontanesi, F Beretti, V Riggio et al, "Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences," BMC Genetics, vol.
Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.
One theory is that redheads have a mutant melanocortin 1 receptor (MC1R) that interacts with endorphins that act as painkillers.
Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation.