MC1R

(redirected from melanocortin 1 receptor)
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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
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References in periodicals archive ?
The extension locus encodes the melanocortin 1 receptor (MC1R) gene that has a seven transmembrane domains protein belonging to the G protein coupled receptors [6].
Sequence characterization and polymorphism of melanocortin 1 receptor gene in some goat breeds with different coat color of Mongolia
Rodgers is the editor of an art magazine called MC1R, for Melanocortin 1 Receptor, which is the name of the gene mutation associated with red hair.
Hundreds of redheads to gather in Hamburg
A melanocortin 1 receptor (MC1R) gene polymorphism is useful for authentication of Massese sheep dairy products.
Differential Expression of the KIT Gene in Liaoning Cashmere Goats with different Coat Colors
On the surface of melanocytes is a protein known as melanocortin 1 receptor, or MC1R.
5 Surprising Facts About Redheads That Make Them Rare
* Stage 1: Binding of melanocyte-stimulating hormone (a-MSH) to the receptor melanocortin 1 receptor (MC1R).
Fade unsightly skin pigmentation
Oh, "Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression," The Journal of Biological Chemistry, vol.
Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants
The 32-year-old, from Castlemilk in Glasgow, has a mutation on the melanocortin 1 receptor (MC1R), a gene located on chromosome 16 of the human genome.
Riddy for anything; THE BIG INTERVIEWRiver City favourite Gary Lamont is so proud to be ginger, he's paying tribute to famous redheads in his one-man Edinburgh Fringe show
[alpha]MSH recognizing melanocortin 1 receptor (MC1R) located on the cell membrane of melanocytes starts a series of signal pathways [1].
Investigation of the novel lead of melanocortin 1 receptor for pigmentary disorders
Fontanesi, F Beretti, V Riggio et al, "Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences," BMC Genetics, vol.
Mutations in MC1R gene determine black coat color phenotype in Chinese sheep
Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.
The effect of hair colour on anaesthetic requirements and recovery time after surgery
One theory is that redheads have a mutant melanocortin 1 receptor (MC1R) that interacts with endorphins that act as painkillers.
Redheads feel more pain: anecdotal evidence suggesting that redheads require more anesthetic than patients with other hair colours has been confirmed by a number of studies
Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation.
Role of estrogen, progesterone and prolactin in the etiopathogenesis of melasma in females

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