MC1R

(redirected from melanocortin 1 receptor)
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MC1R

A gene on chromosome 16q24.3 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase.

Molecular pathology
Genetic variations in MC1R are associated with variation in skin/hair/eye pigmentation type 2, and are linked to cutaneous malignant melanoma type 5.
References in periodicals archive ?
The melanocortin 1 receptor (MC1R) inhibits the inflammatory response in Raw 264.
Two missense mutations in melanocortin 1 receptor (MC1R) are strongly associated with dark ventral coat color in reindeer (Rangifer tarandus).
On the surface of melanocytes is a protein known as melanocortin 1 receptor, or MC1R.
Stage 1: Binding of melanocyte-stimulating hormone (a-MSH) to the receptor melanocortin 1 receptor (MC1R).
The 32-year-old, from Castlemilk in Glasgow, has a mutation on the melanocortin 1 receptor (MC1R), a gene located on chromosome 16 of the human genome.
Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice.
One theory is that redheads have a mutant melanocortin 1 receptor (MC1R) that interacts with endorphins that act as painkillers.
Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation.
We're talking about people with a variant of a gene called the melanocortin 1 receptor that leads to red hair.
We used the MeltCalc software that incorporates the thermodynamic effect of bulges on Tm predictions to design 1 probe with a 40-nt omission in the bovine MC1R melanocortin 1 receptor gene (MC1R), which we then tested experimentally.
The gene that has been studied most widely in this context is the melanocortin 1 receptor gene (MC1R) which is considered a low-penetrance melanoma-predisposing gene.
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.