melanocortin


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melanocortin

Any of a family of peptide hormones, including adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormone (MSH), which are produced endogenously from proopiomelanocortin (POMC) in the pituitary gland or synthesised under controlled chemical reactions. Melanocortins act by binding to and activating melanocortin receptors.
References in periodicals archive ?
M2 PHARMA-February 7, 2018-Palatin Technologies Doses First Human Subjects in Clinical Study of Investigational Melanocortin Receptor 1 Agonist for Treatment of Inflammatory Bowel Diseases
Bremelanotide is thought to possess a novel mechanism of action, activating endogenous melanocortin pathways involved in sexual desire and response.
Pleiotropv in the melanocortin system, coloration and behavioural syndromes.
Melanocortin receptor 1 (MC1R) and its peptide antagonist agouti signaling protein (ASIP) are two major genetic determinants of pigment phenotype in mammals [1,4,5].
On the surface of melanocytes is a protein known as melanocortin 1 receptor, or MC1R.
Stage 1: Binding of melanocyte-stimulating hormone (a-MSH) to the receptor melanocortin 1 receptor (MC1R).
The melanocortin 4 receptor protein regulates the food intake process and body weight in cooperation with leptin and agouti-related protein (AGRP), thus playing an important role in the maintenance of proper body weight (Dhillo et al.
Bremelanotide, a subcutaneous injectable peptide melanocortin receptor agonist, is designed to treat hypoactive sexual desire disorder, the most common form of FSD, in premenopausal women.
The central melanocortin system consists of small peptides, derived from proopiomelanocortin (POMC), which is produced by a subset of neurons located mainly in the hypothalamus and the brainstem.
Among the neurotransmitters and neurohormones thought to promote female sexual function, dopamine and melanocortin are associated with attention and desire, while norepinephrine and oxytocin are more directly related to arousal.
The study, published in Nature Neuroscience, found that melanocortin 4 receptors (MC4Rs) expressed by neurons that control the autonomic nervous system are key in regulating glucose metabolism and energy expenditure, said senior author Dr.