Interestingly, melanocytes were found in the dermis of both the juvenile and adult four-striped mouse which could be associated with migration of the melanoblasts
Murray (1993) also maintains that these color patterns can be produced only if gestation lasts long enough and the embryo is large enough for patterns to occur during the migration of melanoblasts
. He further hypothesized that belted coloration (such as that reported here in a shrew) results from a two-step bifurcation process thought to be possible only in medium-sized mammals.
The cancerous cells of melanoma arise from neuroectodermal melanoblasts
which would have migrated initially through epidermal dermal junctions of skin, follicles and then to dermis during embryonic development.
MITF, a basic helix-loop-helix leucine zipper transcription factor, is located in the center of multiple signaling pathways and acts as a master regulator for differentiation, morphology, proliferation, and survival of melanoblasts
, melanocytes, and melanoma.
The developmental basis may be very similar (at least among rodents) to that described and figured by Stoddart (1970) for the laboratory mouse, Mus musculus, where the spreading activation of melanoblasts
from pigment centers on the body is halted before reaching the terminus of the tail.
Recently, Mica and colleagues  established a stepwise differentiation strategy to obtain functional melanocytes from human pluripotent stem cells by initial NCSC induction, followed by specification of melanoblasts
and eventual differentiation into mature pigmented cells.
Low-energy helium-neon laser induces locomotion of the immature melanoblasts
and promotes melanogenesis of the more differentiated melanoblasts
: recapitulation of vitiligo repigmentation in vitro.
Melanoma is benign tumour of melanoblasts
, the melanin containing cells present in basal layer of epidermis.
Melanomas arise from melanoblasts
present in basal layer of epidermis of skin.
It is postulated that nevus spilus represents a localized defect in neural crest melanoblasts
and occurs in fewer than 0.2% of all newborns and 1.2% of white school children.
A disturbance in metabolism associated with graying might act to stimulate formation of new melanoblasts
or stimulate their activity resulting in focal areas of overproduction in dermis with subsequent tumor production (Theilen and Madwell, 1987).