The LH has 3 distinct populations of neurons: neurons that produce orexin, neurons that produce melanin-concentrating hormone (MCH), and neurons containing isoform 65 of glutamic acid decarboxylase (GAD65), named "GAD65 neurons."
A role for melanin-concentrating hormone in the central regulation of feeding behaviour.
Melanocyte abnormality and destruction, melanin-concentrating hormone
(MCH) MCH receptor autoantibodies, the overexpression of MCH, a high level of homocysteine, an increase in catecholamine, free oxygen radicals, cytomegalovirus and stress may be related to the pathogenesis of vitiligo (14-19).
Within the LHA, neurons expressing the wake-promoting peptides, orexins, are GI neurons, whereas neurons expressing the sleep-promoting neuropeptide melanin-concentrating hormone
(MCH) are GE neurons [19, 20].
Global Markets Direct's, 'Melanin-Concentrating Hormone
Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) - Pipeline Review, H1 2016', provides in depth analysis on Melanin-Concentrating Hormone
Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) targeted pipeline therapeutics.
Cao et al., "The receptor for the orexigenic peptide melanin-concentrating hormone
is a Gprotein-coupled receptor," Nature Cell Biology, vol.
Gammeltoft et al., "A role for melanin-concentrating hormone
in the central regulation of feeding behaviour," Nature, vol.
Vanderbilt's Roger Cone and his team demonstrated that the newly discovered protein, AgRP2, regulates expression of the prohormone genes pmch and pmchl, precursors to melanin-concentrating hormone
, which has a pigment-lightening effect.
SELECTIVE HUMAN MELANIN-CONCENTRATING HORMONE
RECEPTOR 1 AND MELANIN-CONCENTRATING HORMONE
RECEPTOR 2 ANTAGONISTS FOR THE TREATMENT OF METABOLIC DISEASES
is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
The mice are genetically engineered to lack melanin-concentrating hormone
, or MCH, which is made in the brain and is known to stimulate feeding.
The study, led by Shinjae Chung and Olivier Civelli, discovered how the melanin-concentrating hormone
works with dopamine in the brain's "pleasure centre" to create an addictive response to cocaine use.