is another class of anti diabetic drug.
Tolbutamide and gliclazide block channels containing SUR1 ([beta]-cell type) but not SUR2 (cardiac, smooth muscle types), whereas glibenclamide, glimepiride, repaglinide, and meglitinide
block both types of the channels .
The longitudinal retrospective analysis of a large administrative claims database found a 10% incidence of fracture on sulfonylureas and 11% on thiazolidinediones, compared with 7% on biguanides (metformin), 8% on dipeptidyl peptidase-4 (DPP-4) inhibitors, 11% on meglitinide
analogues, and 6% on incretin mimetic agents.
9 mmol/l) in the first few hours after the start of fast, especially if insulin, sulphonylurea drugs or meglitinide
are taken at Sehar.
analogues: a review of clinical data focused on recent trials.
Repaglinide is a meglitinide
, similar to the sutphonylureas but with more rapid onset and shorter duration of action.
Successful combination of oral anti- hyperglycemic agents with their evidence- based recommendation for patients with type 2 diabetes, 2010 Combination Recommendation Metformin + Sulfonylurea A Metformin + Glitazone A Metformin + Acarbose B Metformin + Meglitinide
B Sulfonylurea + Glitazone B Sulfonylurea + Acarbose B Gliptines + Metformin B Meglitinida + Glitazona B Source: ALAD Guidelines (6).
Repaglinide and nateglinide, which are meglitinide
analogs, decrease ATP-sensitive [K.
Prandin, classified as a meglitinide
, lowers blood glucose levels by stimulating the release of insulin from the pancreas and is dependent upon functioning beta cells in the pancreatic islets.
analogues for type 2 diabetes mellitus.
Insulin use and meglitinide
use also resulted in statistically significant increases in the risk of diabetic macular edema (ME), the analysis found.